Publication Name	World Journal of Gastroenterology
Manuscript ID	103512
Country	China

Received	2024-11-22 13:57
Peer-Review Started	2024-11-22 13:57
To Make the First Decision
Return for Revision	2025-02-20 23:45
Revised	2025-03-04 12:15
Second Decision	2025-04-02 02:37
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2025-04-02 04:54
Articles in Press	2025-04-02 04:54
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2025-04-11 03:32
Publish the Manuscript Online	2025-04-18 07:43

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access	This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/
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Category	Gastroenterology & Hepatology
Manuscript Type	Review
Article Title	Management of hepatic encephalopathy following transjugular intrahepatic portosystemic shunts: Current strategies and future directions
Manuscript Source	Invited Manuscript
All Author List	Ying Li, Yu-Tong Wu and Hao Wu
ORCID	Author(s) ORCID Number Ying Li http://orcid.org/0009-0009-0895-5913 Yu-Tong Wu http://orcid.org/0009-0000-0933-8380 Hao Wu http://orcid.org/0000-0002-4573-7968
Funding Agency and Grant Number	Funding Agency Grant Number National Natural Science Foundation of China 82270649
Corresponding Author	Hao Wu, Department of Gastroenterology and Hepatology, West China Hospital, Sichuan University, No. 37 Guoxue Xiang, Chengdu 610041, Sichuan Province, China. 594264513@qq.com
Key Words	Cirrhosis; Portal hypertension; Transjugular intrahepatic portosystemic shunt; Hepatic encephalopathy; Pathophysiological mechanisms; Management strategies
Core Tip	Hepatic encephalopathy (HE) is the main complication following transjugular intrahepatic portosystemic shunt (TIPS), significantly impairs patients’ quality of life. Preoperative evaluation is crucial to mitigate the risk of post-TIPS HE. The shunt diameter and embolization of spontaneous portosystemic shunts should be considered according to the portal pressure gradient. Rifaximin is effective for preventing post-TIPS HE. Endovascular shunt reduction is a potential intervention for refractory HE post-TIPS. Sarcopenia is associated with post-TIPS HE, and the impact of nutritional management on HE following TIPS warrants further investigation. The efficacy of fecal microbiota transplantation in post-TIPS HE requires further validation.
Publish Date	2025-04-18 07:43
Citation	<p>Li Y, Wu YT, Wu H. Management of hepatic encephalopathy following transjugular intrahepatic portosystemic shunts: Current strategies and future directions. <i>World J Gastroenterol</i> 2025; 31(15): 103512</p>
URL	https://www.wjgnet.com/1007-9327/full/v31/i15/103512.htm
DOI	https://dx.doi.org/10.3748/wjg.v31.i15.103512

Full Article (PDF)	WJG-31-103512-with-cover.pdf
Manuscript File	103512_Auto_Edited_014257.docx
Answering Reviewers	103512-answering-reviewers.pdf
Audio Core Tip	103512-audio.mp3
Conflict-of-Interest Disclosure Form	103512-conflict-of-interest-statement.pdf
Copyright License Agreement	103512-copyright-assignment.pdf
Approved Grant Application Form(s) or Funding Agency Copy of any Approval Document(s)	103512-foundation-statement.pdf
Non-Native Speakers of English Editing Certificate	103512-non-native-speakers.pdf
Peer-review Report	103512-peer-reviews.pdf
Scientific Misconduct Check	103512-scientific-misconduct-check.png
Scientific Editor Work List	103512-scientific-editor-work-list.pdf
CrossCheck Report	103512-crosscheck-report.pdf