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Articles Published Processes
1/18/2015 4:09:00 PM | Browse: 1073 | Download: 1238
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Received |
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2014-03-27 21:18 |
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Peer-Review Started |
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2014-03-28 09:29 |
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To Make the First Decision |
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2014-05-29 19:14 |
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Return for Revision |
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2014-06-03 17:42 |
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Revised |
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2014-06-12 17:22 |
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Second Decision |
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2014-07-22 16:54 |
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Accepted by Journal Editor-in-Chief |
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Accepted by Executive Editor-in-Chief |
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2014-07-22 17:15 |
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Articles in Press |
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2014-07-22 18:31 |
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Publication Fee Transferred |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2014-12-27 20:28 |
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Publish the Manuscript Online |
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2015-01-18 16:09 |
| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2015. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Cell Biology |
| Manuscript Type |
Autobiography |
| Article Title |
Aberrant EphB/ephrin-B expression in experimental gastric lesions and tumor cells
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| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Shintaro Uchiyama, Noritaka Saeki and Kazushige Ogawa |
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| Scientific Research from Japan Society for the Promotion of Science |
21580367 (to Ogawa K) |
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| Corresponding Author |
Kazushige Ogawa, DVM, PhD, Department of Veterinary Anatomy, Graduate School of Life and Environmental Sciences, Osaka Prefecture University, 1-58 Rinku-Ourai-Kita, Izumisano, Osaka 598-8531, Japan. kogawa@vet.osakafu-u.ac.jp |
| Key Words |
Gastric ulcer; Gastric dysplasia; Gastric carcinoma cell line; Coexpression; EphB; Ephrin-B |
| Core Tip |
A constant/high level of EphB and ephrin-B coexpression was identified as a feature common to experimentally induced gastric dysplasia and human gastric carcinoma cell lines, as compared to normal and regenerating gastric epithelia. Based on these, we proposed that the stable/robust EphB and ephrin-B coexpression is a marker of dysplastic/oncogenic transformation. Eph signaling in tumor cells likely has a suppressive role during tumor progression, with Eph and ephrin coexpressed on the same cell engaging in non-productive interactions via lateral inhibition and thereby silencing downstream signaling. These results can be useful for the early and accurate diagnosis of gastric tumors. |
| Publish Date |
2015-01-18 16:09 |
| Citation |
Uchiyama S, Saeki N, Ogawa K. Aberrant EphB/ephrin-B expression in experimental gastric lesions and tumor cells. World J Gastroenterol 2015; 21(2): 453-464 |
| URL |
http://www.wjgnet.com/1007-9327/full/v21/i2/453.htm |
| DOI |
http://dx.doi.org/10.3748/wjg.v21.i2.453 |
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