Publication Name	World Journal of Gastroenterology
Manuscript ID	10357
Country	Japan

Received	2014-03-27 21:18
Peer-Review Started	2014-03-28 09:29
First Decision by Editorial Office Director
Return for Revision	2014-06-03 17:42
Revised	2014-06-12 17:22
Publication Fee Transferred
Second Decision by Editor	2014-07-22 16:54
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2014-07-22 17:15
Articles in Press	2014-07-22 18:31
Edit the Manuscript by Language Editor
Typeset the Manuscript	2014-12-27 20:28
Publish the Manuscript Online	2015-01-18 16:09

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright	© The Author(s) 2015. Published by Baishideng Publishing Group Inc. All rights reserved.
Article Reprints	For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions	For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher	Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website	http://www.wjgnet.com

Category	Cell Biology
Manuscript Type	Autobiography
Article Title	Aberrant EphB/ephrin-B expression in experimental gastric lesions and tumor cells
Manuscript Source	Unsolicited Manuscript
All Author List	Shintaro Uchiyama, Noritaka Saeki and Kazushige Ogawa
Funding Agency and Grant Number	Funding Agency Grant Number Scientific Research from Japan Society for the Promotion of Science 21580367 (to Ogawa K)
Corresponding Author	Kazushige Ogawa, DVM, PhD, Department of Veterinary Anatomy, Graduate School of Life and Environmental Sciences, Osaka Prefecture University, 1-58 Rinku-Ourai-Kita, Izumisano, Osaka 598-8531, Japan. kogawa@vet.osakafu-u.ac.jp
Key Words	Gastric ulcer; Gastric dysplasia; Gastric carcinoma cell line; Coexpression; EphB; Ephrin-B
Core Tip	A constant/high level of EphB and ephrin-B coexpression was identified as a feature common to experimentally induced gastric dysplasia and human gastric carcinoma cell lines, as compared to normal and regenerating gastric epithelia. Based on these, we proposed that the stable/robust EphB and ephrin-B coexpression is a marker of dysplastic/oncogenic transformation. Eph signaling in tumor cells likely has a suppressive role during tumor progression, with Eph and ephrin coexpressed on the same cell engaging in non-productive interactions via lateral inhibition and thereby silencing downstream signaling. These results can be useful for the early and accurate diagnosis of gastric tumors.
Publish Date	2015-01-18 16:09
Citation	Uchiyama S, Saeki N, Ogawa K. Aberrant EphB/ephrin-B expression in experimental gastric lesions and tumor cells. World J Gastroenterol 2015; 21(2): 453-464
URL	http://www.wjgnet.com/1007-9327/full/v21/i2/453.htm
DOI	http://dx.doi.org/10.3748/wjg.v21.i2.453

Full Article (PDF)	WJG-21-453.pdf
Full Article (Word)	WJG-21-453.doc
Manuscript File	10357-Review.doc
Answering Reviewers	10357-Answering reviewers.pdf
Copyright License Agreement	10357-Copyright assignment.pdf
Non-Native Speakers of English Editing Certificate	10357-Language certificate.pdf
Peer-review Report	10357-Peer review(s).pdf
Scientific Misconduct Check	10357-CrossCheck.jpg
Scientific Editor Work List	10357-Scientific editor work list.pdf