| ISSN |
1948-5204 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2024. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
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| Permissions |
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Oncology |
| Manuscript Type |
Basic Study |
| Article Title |
Exploring the potential function of high expression of ANAPC1 in regulating ubiquitination in hepatocellular carcinoma
|
| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Yu-Xing Tang, Wei-Zi Wu, Sheng-Sheng Zhou, Da-Tong Zeng, Guang-Cai Zheng, Rong-Quan He, Di-Yuan Qin, Wan-Ying Huang, Ji-Tian Chen, Yi-Wu Dang, Yu-Lu Tang, Bang-Teng Chi, Yan-Ting Zhan and Gang Chen |
| ORCID |
|
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| National Natural Science Foundation of China |
No. NSFC82160762 |
| National Natural Science Foundation of China |
No. NSFC82460783 |
| Innovation Project of Guangxi Graduate Education |
No. JGY2023068 |
| Guangxi Higher Education Undergraduate Teaching Reform Project |
No. 2022JGA146 |
| Guangxi Zhuang Autonomous Region Health Commission Scientific Research Project |
No. Z-A20220469 |
| Future Academic Star of Guangxi Medical University |
No. WLXSZX24074 |
| China Undergraduate Innovation and Entrepreneurship Training Program |
No. X202410598360 |
|
| Corresponding Author |
Gang Chen, Professor, Department of Pathology, The First Affiliated Hospital of Guangxi Medical University, No. 6 Shuangyong Road, Nanning 530021, Guangxi Zhuang Autonomous Region, China. chengang@gxmu.edu.cn |
| Key Words |
Hepatocellular carcinoma; ANAPC1; Ubiquitination; Gene expression; Molecular mechanism |
| Core Tip |
ANAPC1, a key ubiquitination regulator in tumours, remains unstudied in hepatocellular carcinoma (HCC). This first multicenter study on ANAPC1 in HCC shows its high expression in bulk RNA (n = 3913, including RNA sequencing and microarray), immunohistochemistry (n = 632) and single-cell RNA sequencing (15999 malignant hepatocytes). Clustered regularly interspaced short palindromic repeats knockout of ANAPC1 inhibited HCC cell proliferation. Gene set enrichment analysis, gene ontology and Kyoto encyclopedia of genes and genomes analyses revealed the role of the high expression of ANAPC1 in ubiquitin-mediated protein degradation, which may affect the G2/M phase and glycolysis, regulate migration inhibitory factor signalling and enhance HCC sensitivity to sorafenib, dasatinib, ibrutinib, lapatinib, nilotinib and afatinib. |
| Publish Date |
2025-05-15 10:28 |
| Citation |
<p>Tang YX, Wu WZ, Zhou SS, Zeng DT, Zheng GC, He RQ, Qin DY, Huang WY, Chen JT, Dang YW, Tang YL, Chi BT, Zhan YT, Chen G. Exploring the potential function of high expression of ANAPC1 in regulating ubiquitination in hepatocellular carcinoma. <i>World J Gastrointest Oncol</i> 2025; 17(5): 103594</p> |
| URL |
https://www.wjgnet.com/1948-5204/full/v17/i5/103594.htm |
| DOI |
https://dx.doi.org/10.4251/wjgo.v17.i5.103594 |
