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3/18/2025 7:12:46 AM | Browse: 77 | Download: 340
Publication Name World Journal of Clinical Pediatrics
Manuscript ID 103608
Country Switzerland
Received
2024-11-25 07:42
Peer-Review Started
2024-11-25 07:43
First Decision by Editorial Office Director
2025-01-20 06:12
Return for Revision
2025-01-20 06:12
Revised
2025-01-23 09:09
Publication Fee Transferred
Second Decision by Editor
2025-02-14 02:38
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director
2025-02-14 09:17
Articles in Press
2025-02-14 09:17
Edit the Manuscript by Language Editor
2025-02-17 23:12
Typeset the Manuscript
2025-03-03 03:47
Publish the Manuscript Online
2025-03-18 07:12
ISSN 2219-2808 (online)
Open Access This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Copyright © The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved.
Article Reprints For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Category Gastroenterology & Hepatology
Manuscript Type Editorial
Article Title Disorders of gut-brain interaction are a new challenge of our increasingly complex society, with worldwide repercussions
Manuscript Source Invited Manuscript
All Author List Earl B Ettienne and Klaus Rose
ORCID
Author(s) ORCID Number
Earl B Ettienne http://orcid.org/0000-0002-5859-3086
Klaus Rose http://orcid.org/0000-0002-8304-1822
Funding Agency and Grant Number
Corresponding Author Klaus Rose, Chief Physician, MD, Pediatric Drug Development and More, Medical Science, Äussere Baselstrasse 308, Riehen CH-4125, Switzerland. klaus.rose@klausrose.net
Key Words Disorders of gut-brain interaction; American Psychiatric Association; Rome foundation; Rome IV; Gut-brain-axis; Functional diseases; Psychiatric diseases; Mechanistic approaches; Symptom-based criteria; Clinical trials; Drugs; Biologics
Core Tip Disorders of gut-brain interaction can seriously challenge patients‘ health and quality of life (QoL). This new approach does no longer differentiate organic from functional (or psychiatric) disorders. This former, now outdated distinction did not help patients whose QoL was and is seriously impaired. Instead, today symptom-based criteria attempt to better understand patients where traditional explanation did neither allow satisfying clinical treatment nor inclusion into exploratory trials with new drugs or biologics. With this new approach, it is hoped to overcome shortcomings of traditional attempts to help.
Publish Date 2025-03-18 07:12
Citation

Ettienne EB, Rose K. Disorders of gut-brain interaction are a new challenge of our increasingly complex society, with worldwide repercussions. World J Clin Pediatr 2025; 14(2): 103608

URL https://www.wjgnet.com/2219-2808/full/v14/i2/103608.htm
DOI https://dx.doi.org/10.5409/wjcp.v14.i2.103608
Full Article (PDF) WJCP-14-103608-with-cover.pdf
Manuscript File 103608_Auto_Edited_084124.docx
Answering Reviewers 103608-answering-reviewers.pdf
Audio Core Tip 103608-audio.mp3
Conflict-of-Interest Disclosure Form 103608-conflict-of-interest-statement.pdf
Copyright License Agreement 103608-copyright-assignment.pdf
Non-Native Speakers of English Editing Certificate 103608-non-native-speakers.pdf
Peer-review Report 103608-peer-reviews.pdf
Scientific Misconduct Check 103608-scientific-misconduct-check.png
Scientific Editor Work List 103608-scientific-editor-work-list.pdf
CrossCheck Report 103608-crosscheck-report.pdf