Publication Name	World Journal of Clinical Cases
Manuscript ID	103642
Country	United States

Received	2024-11-26 10:51
Peer-Review Started	2024-11-26 10:51
To Make the First Decision
Return for Revision	2025-01-16 01:06
Revised	2025-01-28 22:24
Second Decision	2025-03-27 02:39
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2025-03-27 08:36
Articles in Press	2025-03-27 08:36
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2025-04-16 10:30
Publish the Manuscript Online	2025-04-27 07:06

ISSN	2307-8960 (online)
Open Access	This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
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Category	Endocrinology & Metabolism
Manuscript Type	Case Report
Article Title	Hypophosphatasia: A case report
Manuscript Source	Invited Manuscript
All Author List	Angad Singh Gill, Pallavi Sharma, Mahmoud Nassar and Erlin Marte
ORCID	Author(s) ORCID Number Mahmoud Nassar http://orcid.org/0000-0002-5401-9562
Funding Agency and Grant Number
Corresponding Author	Mahmoud Nassar, MD, PhD, Postdoctoral Fellow, Department of Research, American Society for Inclusion, Diversity, and Equity in Healthcare, 705 Maple Road, Lewes, NY 19958, United States. nassarma@asidehealthcare.org
Key Words	Hypophosphatasia; Tissue-nonspecific alkaline phosphatase; Osteopenia; Enzyme replacement therapy; Asfotase alfa; Low alkaline phosphatase levels; Vitamin B6 metabolism; Skeletal hypomineralization; Rare metabolic disorders; Adult-onset hypophosphatasia; Case report
Core Tip	This case report highlights the importance of considering hypophosphatasia (HPP) in patients with unexplained bone pain and low alkaline phosphatase levels, especially in the presence of osteopenia or osteoporosis. It underscores the role of genetic testing and counseling in diagnosing and managing HPP, emphasizing early identification and treatment to improve patient outcomes. The report also illustrates how HPP can explain multiple symptoms often misdiagnosed as conditions like fibromyalgia. Additionally, it aims to raise awareness about enzyme replacement therapies that can significantly improve quality of life and reduce complications for HPP patients.
Publish Date	2025-04-27 07:06
Citation	<p>Gill AS, Sharma P, Nassar M, Marte E. Hypophosphatasia: A case report. <i>World J Clin Cases</i> 2025; 13(21): 103642</p>
URL	https://www.wjgnet.com/2307-8960/full/v13/i21/103642.htm
DOI	https://dx.doi.org/10.12998/wjcc.v13.i21.103642

Full Article (PDF)	WJCC-13-103642-with-cover.pdf
CARE Checklist–2016	103642-CARE-Checklist-2016.pdf
Manuscript File	103642_Auto_Edited_124609.docx
Answering Reviewers	103642-answering-reviewers.pdf
Audio Core Tip	103642-audio.mp3
Conflict-of-Interest Disclosure Form	103642-conflict-of-interest-statement.pdf
Copyright License Agreement	103642-copyright-assignment.pdf
Signed Consent for Treatment Form(s) or Document(s)	103642-informed-consent-statement.pdf
Peer-review Report	103642-peer-reviews.pdf
Scientific Misconduct Check	103642-scientific-misconduct-check.png
Scientific Editor Work List	103642-scientific-editor-work-list.pdf
CrossCheck Report	103642-crosscheck-report.pdf