Publication Name	World Journal of Clinical Pediatrics
Manuscript ID	103652
Country	Russia

Received	2024-11-26 01:00
Peer-Review Started	2024-11-26 01:01
To Make the First Decision
Return for Revision	2025-02-20 03:07
Revised	2025-03-06 17:10
Second Decision	2025-03-18 02:43
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2025-03-18 10:35
Articles in Press	2025-03-18 10:35
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2025-04-10 03:27
Publish the Manuscript Online	2025-06-16 10:38

ISSN	2219-2808 (online)
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Category	Pediatrics
Manuscript Type	Basic Study
Article Title	MicroRNA-320а as a novel biomarker at preclinical stage of necrotizing enterocolitis in term neonates with congenital heart defects
Manuscript Source	Invited Manuscript
All Author List	Ekaterina K Zaikova, Aleksandra V Kaplina, Natalia A Petrova, Tatiana M Pervunina, Alexey S Golovkin, Anna A Kostareva and Olga V Kalinina
ORCID	Author(s) ORCID Number Ekaterina K Zaikova http://orcid.org/0000-0003-0584-2330 Aleksandra V Kaplina http://orcid.org/0000-0001-6939-6961 Natalia A Petrova http://orcid.org/0000-0002-0479-0850 Tatiana M Pervunina http://orcid.org/0000-0001-9948-7303 Alexey S Golovkin http://orcid.org/0000-0002-7577-628X Anna A Kostareva http://orcid.org/0000-0002-9349-6257 Olga V Kalinina http://orcid.org/0000-0003-1916-5705
Funding Agency and Grant Number	Funding Agency Grant Number The Russian Science Foundation No. 19-75-20076
Corresponding Author	Olga V Kalinina, PhD, Professor, Department of Laboratory Medicine with Clinic, Institution of Medical Education, Almazov National Medical Research Centre, Akkuratova Street 2, Saint-Petersburg 197341, Russia. olgakalinina@mail.ru
Key Words	MicroRNA-320a; Term newborns; Necrotizing enterocolitis; Congenital heart defects; Plasma biomarker; Quantitative real-time polymerase chain reaction
Core Tip	The high morbidity and mortality rates associated with necrotizing enterocolitis (NEC) highlight the critical need to identify specific and sensitive biomarkers for early detection and prevention. In this study we evaluated plasma levels of microRNA (miR)-155, miR-221, miR-223, miR-320a, and miR-451a as potential NEC biomarkers in term newborns with congenital heart defects (CHD). For the first time, plasma miR-320a-3p was identified as a predictive biomarker for the risk of NEC in term newborns with CHD at the preclinical stage, and the Hippo signaling pathway may be involved in the early stages of NEC pathogenesis.
Publish Date	2025-06-16 10:38
Citation	<p>Zaikova EK, Kaplina AV, Petrova NA, Pervunina TM, Golovkin AS, Kostareva AA, Kalinina OV. MicroRNA-320а as a novel biomarker at preclinical stage of necrotizing enterocolitis in term neonates with congenital heart defects. <i>World J Clin Pediatr</i> 2025; 14(3): 103652</p>
URL	https://www.wjgnet.com/2219-2808/full/v14/i3/103652.htm
DOI	https://dx.doi.org/10.5409/wjcp.v14.i3.103652

Full Article (PDF)	WJCP-14-103652-with-cover.pdf
The ARRIVE Guidelines	103652-The-ARRIVE-Guidelines.pdf
Manuscript File	103652_Auto_Edited_080844.docx
Answering Reviewers	103652-answering-reviewers.pdf
Audio Core Tip	103652-audio.m4a
Biostatistics Review Certificate	103652-biostatistics-statement.pdf
Conflict-of-Interest Disclosure Form	103652-conflict-of-interest-statement.pdf
Copyright License Agreement	103652-copyright-assignment.pdf
Approved Grant Application Form(s) or Funding Agency Copy of any Approval Document(s)	103652-foundation-statement.pdf
Institutional Review Board Approval Form or Document	103652-institutional-review-board-statement.pdf
Non-Native Speakers of English Editing Certificate	103652-non-native-speakers.pdf
Peer-review Report	103652-peer-reviews.pdf
Scientific Misconduct Check	103652-scientific-misconduct-check.png
Scientific Editor Work List	103652-scientific-editor-work-list.pdf
CrossCheck Report	103652-crosscheck-report.pdf