Publication Name	World Journal of Gastrointestinal Surgery
Manuscript ID	103740
Country	China

Received	2024-12-03 13:15
Peer-Review Started	2024-12-03 13:15
To Make the First Decision
Return for Revision	2024-12-20 13:04
Revised	2025-01-01 13:27
Second Decision	2025-01-14 02:43
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2025-01-14 08:40
Articles in Press	2025-01-14 08:40
Publication Fee Transferred	2025-01-08 01:11
Edit the Manuscript by Language Editor
Typeset the Manuscript	2025-01-22 10:11
Publish the Manuscript Online	2025-02-24 09:26

ISSN	1948-9366 (online)
Open Access	This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
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Category	Gastroenterology & Hepatology
Manuscript Type	Minireviews
Article Title	Neoadjuvant therapy: Dawn of reducing the high post-surgery recurrence rate of hepatocellular carcinoma
Manuscript Source	Unsolicited Manuscript
All Author List	Xiao-Dong Zhang, Lu-Yi Zhang, Jia-Liang Luo, Ke-Heng Yu and Ke-Lei Zhu
ORCID	Author(s) ORCID Number Xiao-Dong Zhang http://orcid.org/0009-0001-8664-3810 Ke-Lei Zhu http://orcid.org/0000-0001-6497-3379
Funding Agency and Grant Number	Funding Agency Grant Number the Zhejiang Provincial Medical and Health Science and Technology Plan 2022ZH050 the Health Science and Technology Project of Yinzhou District 2023Y03
Corresponding Author	Ke-Lei Zhu, Chief Physician, MD, PhD, Department of Hepatopancreatobiliary Surgery, The Affiliated People's Hospital of Ningbo University, No. 251 Baizhang East Road, Ningbo 315040, Zhejiang Province, China. dr.zkl@163.com
Key Words	Hepatocellular carcinoma; Neoadjuvant therapy; Locoregional therapy; Molecularly targeted drug; Immune checkpoint inhibitor
Core Tip	Currently, numerous articles focus on preoperative antitumor therapy for hepatocellular carcinoma (HCC). Of note, this review uniquely examines neoadjuvant therapy for HCC within the context of combination therapy from the perspective of the China Liver Cancer Stage. Drawing on the Chinese guidelines, it addresses the definition of the neoadjuvant therapy concept, identifies the target population, evaluates the outcomes of various treatment strategies, and discusses the challenges regarding neoadjuvant therapy for HCC.
Publish Date	2025-02-24 09:26
Citation	<p>Zhang XD, Zhang LY, Luo JL, Yu KH, Zhu KL. Neoadjuvant therapy: Dawn of reducing the high post-surgery recurrence rate of hepatocellular carcinoma. <i>World J Gastrointest Surg</i> 2025; 17(3): 103740</p>
URL	https://www.wjgnet.com/1948-9366/full/v17/i3/103740.htm
DOI	https://dx.doi.org/10.4240/wjgs.v17.i3.103740

Full Article (PDF)	WJGS-17-103740-with-cover.pdf
Manuscript File	103740_Auto_Edited_085536.docx
Answering Reviewers	103740-answering-reviewers.pdf
Audio Core Tip	103740-audio.m4a
Conflict-of-Interest Disclosure Form	103740-conflict-of-interest-statement.pdf
Copyright License Agreement	103740-copyright-assignment.pdf
Approved Grant Application Form(s) or Funding Agency Copy of any Approval Document(s)	103740-foundation-statement.pdf
Non-Native Speakers of English Editing Certificate	103740-non-native-speakers.pdf
Supplementary Material	103740-supplementary-material.pdf
Peer-review Report	103740-peer-reviews.pdf
Scientific Misconduct Check	103740-scientific-misconduct-check.png
Scientific Editor Work List	103740-scientific-editor-work-list.pdf
CrossCheck Report	103740-crosscheck-report.png
CrossCheck Report	103740-crosscheck-report.pdf