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Articles Published Processes
11/28/2025 2:00:37 PM | Browse: 15 | Download: 59
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Received |
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2024-12-04 08:52 |
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Peer-Review Started |
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2024-12-05 05:56 |
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First Decision by Editorial Office Director |
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2025-02-25 08:05 |
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Return for Revision |
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2025-02-25 08:05 |
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Revised |
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2025-04-01 01:59 |
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Publication Fee Transferred |
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Second Decision by Editor |
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2025-06-06 02:45 |
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Second Decision by Editor-in-Chief |
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Final Decision by Editorial Office Director |
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2025-06-07 02:06 |
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Articles in Press |
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2025-06-07 02:06 |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2025-08-25 02:49 |
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Publish the Manuscript Online |
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2025-11-28 14:00 |
| ISSN |
2220-3141(online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Surgery |
| Manuscript Type |
Clinical Trials Study |
| Article Title |
Efficacy and safety of exosomes from Wharton’s Jelly-derived mesenchymal stem cells in traumatic brain injury
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| Manuscript Source |
Invited Manuscript |
| All Author List |
Serdar Kabatas, Erdinç Civelek, Eyüp Can Savrunlu, Necati Kaplan, Tunç Akkoc, Nurten Küçükçakır, Mehmet Bozkurt and Erdal Karaöz |
| ORCID |
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| Funding Agency and Grant Number |
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| Corresponding Author |
Serdar Kabatas, Department of Neurosurgery, University of Health Sciences Turkey, Gaziosmanpaşa Training and Research Hospital, Karayolları Mahallesi, Osmanbey Caddesi 616. Sokak No. 10, Gaziosmanpaşa, Istanbul 34255, Türkiye. kabatasserdar@hotmail.com |
| Key Words |
Exosome therapy; Mesenchymal stem cells; Neuroprotection; Traumatic brain injury; Neuroregeneration |
| Core Tip |
Mesenchymal stem cell-derived exosomes (MSCdE) therapy shows promise for traumatic brain injury (TBI) patients, with significant improvements in motor and cognitive function reflected in functional independence measure scores. The treatment was well tolerated, with mild, temporary side effects such as subfebrile fever and pain, and no serious adverse events reported. Enhanced Karnofsky Performance Scale scores suggest improved quality of life and functional status, supporting its potential for long-term recovery. While spasticity improvement was observed, it was not statistically significant, possibly due to mild baseline spasticity. These findings support MSCdE therapy as a potential treatment for TBI, warranting further validation through larger randomized controlled trials. |
| Publish Date |
2025-11-28 14:00 |
| Citation |
Kabatas S, Civelek E, Savrunlu EC, Kaplan N, Akkoc T, Küçükçakır N, Bozkurt M, Karaöz E. Efficacy and safety of exosomes from Wharton’s Jelly-derived mesenchymal stem cells in traumatic brain injury. World J Crit Care Med 2025; 14(4): 103782 |
| URL |
https://www.wjgnet.com/2220-3141/full/v14/i4/103782.htm |
| DOI |
https://dx.doi.org/10.5492/wjccm.v14.i4.103782 |
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