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Publication Name World Journal of Gastrointestinal Oncology
Manuscript ID 103808
Country China
Received
2024-12-02 14:21
Peer-Review Started
2024-12-02 14:21
To Make the First Decision
Return for Revision
2025-02-10 08:17
Revised
2025-06-21 04:57
Second Decision
2025-07-07 02:40
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief
2025-07-07 07:50
Articles in Press
2025-07-07 07:50
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript
2025-11-03 08:05
Publish the Manuscript Online
2025-11-14 00:56
ISSN 1948-5204 (online)
Open Access This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Copyright © The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved.
Article Reprints For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Category Gastroenterology & Hepatology
Manuscript Type Letter to the Editor
Article Title Innovative insights and future research directions in gastric cancer through single-cell RNA sequencing
Manuscript Source Invited Manuscript
All Author List Cheng-Fei Zhao, Qu-Wen Li, Shen-Yi Ye, Li-Wen Chen and Zhi-Feng Xu
ORCID
Author(s) ORCID Number
Cheng-Fei Zhao http://orcid.org/0000-0002-6646-6327
Qu-Wen Li http://orcid.org/0000-0002-6145-858X
Zhi-Feng Xu http://orcid.org/0009-0003-8235-0548
Funding Agency and Grant Number
Funding Agency Grant Number
Scientific Research Project of Putian University 2022059
Special Project for Outstanding Young Talents of Putian University 2024072
Natural Science Foundation of Fujian Province 2023J01160
Corresponding Author Zhi-Feng Xu, Chief Physician, Department of Cardiothoracic Surgery, Affiliated Hospital of Putian University, No. 999 Dongzhen Road, Licheng District, Putian 351100, Fujian Province, China. zhifengxu1972@163.com
Key Words Gastric cancer; Single-cell RNA sequencing; Tumor microenvironment; Immune cells; Paracancerous tissues; Multi-omics approaches; Spatial transcriptomics; Artificial intelligence; Immune modulation; Early detection
Core Tip Gastric cancer (GC) remains a major global health challenge, with low survival rates due to tumor heterogeneity and complex progression mechanisms. The recent study by Tang et al provides valuable insights into the dynamic changes in the tumor microenvironment across different GC stages using single-cell RNA sequencing. We summarize the study's key findings and propose future research directions, such as multi-omics approaches, spatial transcriptomics, integration of artificial intelligence into clinical practice, and innovative immunotherapies. By emphasizing personalized medicine and early detection, these advancements demonstrate significant potential for enhancing treatment outcomes in GC and refining therapeutic strategies.
Publish Date 2025-11-14 00:56
Citation <p>Zhao CF, Li QW, Ye SY, Chen LW, Xu ZF. Innovative insights and future research directions in gastric cancer through single-cell RNA sequencing. <i>World J Gastrointest Oncol</i> 2025; 17(11): 103808</p>
URL https://www.wjgnet.com/1948-5204/full/v17/i11/103808.htm
DOI https://dx.doi.org/10.4251/wjgo.v17.i11.103808
Full Article (PDF) WJGO-17-103808-with-cover.pdf
Manuscript File 103808_Auto_Edited_073549.docx
Answering Reviewers 103808-answering-reviewers.pdf
Audio Core Tip 103808-audio.mp3
Conflict-of-Interest Disclosure Form 103808-conflict-of-interest-statement.pdf
Copyright License Agreement 103808-copyright-assignment.pdf
Non-Native Speakers of English Editing Certificate 103808-non-native-speakers.pdf
Peer-review Report 103808-peer-reviews.pdf
Scientific Misconduct Check 103808-scientific-misconduct-check.png
Scientific Editor Work List 103808-scientific-editor-work-list.pdf
CrossCheck Report 103808-crosscheck-report.pdf