Publication Name	World Journal of Gastroenterology
Manuscript ID	10381
Country	Brazil

Received	2014-03-29 11:25
Peer-Review Started	2014-03-29 14:32
To Make the First Decision	2014-05-13 20:18
Return for Revision	2014-05-21 08:54
Revised	2014-05-28 00:00
Second Decision	2014-07-11 16:59
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2014-07-11 17:22
Articles in Press	2014-07-11 17:34
Publication Fee Transferred
Edit the Manuscript by Language Editor	2014-07-23 05:58
Typeset the Manuscript	2014-10-26 22:02
Publish the Manuscript Online	2014-11-10 19:10

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access
Copyright
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Publisher	Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website	http://www.wjgnet.com

Category	Gastroenterology & Hepatology
Manuscript Type	Autobiography
Article Title	Beneficial effects of adenosine triphosphate-sensitive K+ channel opener on liver ischemia/reperfusion injury
Manuscript Source	Unsolicited Manuscript
All Author List	Mateus Antunes Nogueira, Ana Maria Mendonça Coelho, Sandra Nassa Sampietre, Rosely Antunes Patzina, Fabiano Pinheiro da Silva, Luiz Augusto Carneiro D'Albuquerque and Marcel Cerqueira Cesar Machado
Funding Agency and Grant Number	Funding Agency Grant Number Fundação de Amparo à Pesquisa do Estado de São Paulo 2010/19078-1
Corresponding Author	Marcel Cerqueira Cesar Machado, MD, Professor of Medicine, Department of Clinical Emergency (LIM/51), Medical School, University of Sao Paulo, R. Peixoto Gomide, 515 13 andar 01409001, Sao Paulo 01246903, Brazil. mccm37@uol.com.br
Key Words	Liver ischemia/reperfusion; Diazoxide; K+ channel opener; Mitochondrial ATP-sensitive potassium channel; Liver mitochondria
Core Tip	Diazoxide is a selective mitoKATP channel opener and has a protective effect against organ ischemia/reperfusion (I/R) injury. This report shows that diazoxide maintains liver mitochondrial function, increases liver tolerance to I/R injury, and reduces the systemic inflammatory response. Since diazoxide has also a hypotensive effect its administration may also reduce bleeding in liver surgery during hepatic parenchyma transection. These effects require further evaluation for use in a clinical setting.
Publish Date	2014-11-10 19:10
Citation	Nogueira MA, Coelho AMM, Sampietre SN, Patzina RA, Pinheiro da Silva F, D’Albuquerque LAC, Machado MCC. Beneficial effects of adenosine triphosphate-sensitive K+ channel opener on liver ischemia/reperfusion injury. World J Gastroenterol 2014; 20(41): 15319-15326
URL	http://www.wjgnet.com/1007-9327/full/v20/i41/15319.htm
DOI	http://dx.doi.org/10.3748/wjg.v20.i41.15319

Full Article (PDF)	WJG-20-15319.pdf
Full Article (Word)	WJG-20-15319.doc
Manuscript File	10381-Review.docx
Answering Reviewers	10381-Answering reviewers.pdf
Copyright License Agreement	10381-Copyright assignment.pdf
Institutional Review Board Approval Form or Document	Ethics_Committee_20140328200957.docx
Peer-review Report	10381-Peer review.pdf
Scientific Misconduct Check	10381-CrossCheck.jpg
Scientific Editor Work List	10381-Scientific editor work list.pdf