| ISSN |
2218-4333 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Oncology |
| Manuscript Type |
Basic Study |
| Article Title |
Homeobox C6 plays an oncogenic role in bladder cancer
|
| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Ding-Jin Lu, Hai-Rong Wang, You-Sheng Xu, Hai-Bo Huang, Qi-Gang Zhong, Yuan-Ning Luo, Jian-Feng Qi, Hong-Chao Wu, Jin-Ye Pei, Kun Zhang, Chao-Xiong Xu, Tian-Xian Wang, Wei Zhang, Yu-Hong Zhou, Zhi-Guang Huang and Fu-Bo Wang |
| ORCID |
|
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| Science and Technology Major Project of Guangxi |
AA22096030 and AA22096032 |
| Yongjiang Program of Nanning; the Creative Research Development from the First Affiliated Hospital of Guangxi Medical University |
Medical Excellence Award 202303 |
| Guangxi Medical University Undergraduate Education and Teaching Reform Project |
2024XJGYC20 |
| Guangxi Medical University Student Innovation and Entrepreneurship Training Program Project |
202310598002X and 202310598041 |
| Guangxi Medical University Student Innovation and Entrepreneurship Training Program Project |
202410598039X and 202410598044 |
| The “Future Academic Star” of the Guangxi Medical University |
WLXSZX24096 |
|
| Corresponding Author |
Fu-Bo Wang, PhD, Professor, Center for Genomic and Personalized Medicine, Guangxi key Laboratory for Genomic and Personalized Medicine, Guangxi Collaborative Innovation Center for Genomic and Personalized Medicine, University Engineering Research Center of Digital Medicine and Healthcare, Guangxi Medical University, No. 22 Shuangyong Road, Nanning 530021, Guangxi Zhuang Autonomous Region, China. wangfubo@gxmu.edu.cn |
| Key Words |
Homeobox C6; Bladder cancer; Timeless circadian regulator; Cellular function; Transcriptional regulation |
| Core Tip |
Homeobox C6 (HOXC6) is an HOX family gene that has an oncogenic effect in various malignancies. Our study showed the increased expression levels of HOXC6 at the protein and mRNA levels. Down-regulated HOXC6 considerably limited the function of cell proliferation, migration, and invasion abilities of BLCA cells, elevated cell apoptosis, and triggered the G0/G1 phase blockade. HOXC6 may influence the cellular functions of BLCA by regulating the expression of the target gene timeless circadian regulator (TIMELESS), with the evidence of positive correlation between HOXC6 and TIMELESS and the binding peak signals for HOXC6 in the promoter region of TIMELESS. |
| Publish Date |
2025-05-20 03:37 |
| Citation |
<p>Lu DJ, Wang HR, Xu YS, Huang HB, Zhong QG, Luo YN, Qi JF, Wu HC, Pei JY, Zhang K, Xu CX, Wang TX, Zhang W, Zhou YH, Huang ZG, Wang FB. Homeobox C6 plays an oncogenic role in bladder cancer. <i>World J Clin Oncol</i> 2025; 16(5): 103830</p> |
| URL |
https://www.wjgnet.com/2218-4333/full/v16/i5/103830.htm |
| DOI |
https://dx.doi.org/10.5306/wjco.v16.i5.103830 |
