Publication Name	World Journal of Hepatology
Manuscript ID	103839
Country	China

Received	2024-12-04 09:38
Peer-Review Started	2024-12-06 00:13
To Make the First Decision
Return for Revision	2025-01-03 09:46
Revised	2025-01-29 15:01
Second Decision	2025-02-26 02:42
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2025-02-27 10:47
Articles in Press	2025-02-27 10:47
Publication Fee Transferred	2025-01-31 15:56
Edit the Manuscript by Language Editor
Typeset the Manuscript	2025-03-19 01:42
Publish the Manuscript Online	2025-03-26 04:06

ISSN	1948-5182 (online)
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Category	Gastroenterology & Hepatology
Manuscript Type	Review
Article Title	Research progress on the roles of complement in liver injury
Manuscript Source	Unsolicited Manuscript
All Author List	Li-Li Ou, Jin-Lian Jiang, Man-Lu Guo, Jin-Hua Wu, Wei-Wei Zhong and Yi-Huai He
ORCID	Author(s) ORCID Number Li-Li Ou http://orcid.org/0009-0002-5293-0309 Jin-Lian Jiang http://orcid.org/0000-0002-0791-9680 Wei-Wei Zhong http://orcid.org/0000-0002-9736-8148 Yi-Huai He http://orcid.org/0000-0002-8639-3436
Funding Agency and Grant Number	Funding Agency Grant Number Science and Technology Planning Projects of Guizhou Province QKHJC-ZK[2022]YB642 Science and Technology Planning Projects of Zunyi City ZSKHHZ (2022)344 WBE Liver Fibrosis Foundation CFHPC2025028 Chinese Foundation for Hepatitis Prevention and Control Muxin Research Fund of CHB MX202404 Beijing Liver and Gallbladder Mutual Aid Public Welfare Foundation Artificial Liver Special Fund iGandanF-1082024-Rgg018 Graduate Research Fund Project of Zunyi Medical University ZYK246 Student Innovation and Entrepreneurship Training Program of Zunyi Medical University 2024106610923 and S202310661028
Corresponding Author	Yi-Huai He, Associate Chief Physician, MD, Department of Infectious Diseases, The Affiliated Hospital of Zunyi Medical University, No. 149 Dalian Road, Huichuan District, Zunyi 563000, Guizhou Province, China. 993565989@qq.com
Key Words	Complement system; Liver injury; Immune homeostasis; Pathogenesis; Review
Core Tip	This review details the intricate relationship between the complement system and liver injury, highlighting its dual role in the pathology of liver injury. Although essential for immune response initiation, the complement system can also exacerbate liver injury. We synthesize current knowledge on the complement's involvement in liver injury, aiming to inform the creation of novel therapies that modulate this system to promote liver repair or halt disease progression. Future research directions and potential pharmaceutical targets are also discussed.
Publish Date	2025-03-26 04:06
Citation	<p>Ou LL, Jiang JL, Guo ML, Wu JH, Zhong WW, He YH. Research progress on the roles of complement in liver injury. <i>World J Hepatol</i> 2025; 17(3): 103839</p>
URL	https://www.wjgnet.com/1948-5182/full/v17/i3/103839.htm
DOI	https://dx.doi.org/10.4254/wjh.v17.i3.103839

Full Article (PDF)	WJH-17-103839-with-cover.pdf
Manuscript File	103839_Auto_Edited_022745.docx
Answering Reviewers	103839-answering-reviewers.pdf
Audio Core Tip	103839-audio.m4a
Conflict-of-Interest Disclosure Form	103839-conflict-of-interest-statement.pdf
Copyright License Agreement	103839-copyright-assignment.pdf
Approved Grant Application Form(s) or Funding Agency Copy of any Approval Document(s)	103839-foundation-statement.pdf
Non-Native Speakers of English Editing Certificate	103839-non-native-speakers.pdf
Peer-review Report	103839-peer-reviews.pdf
Scientific Misconduct Check	103839-scientific-misconduct-check.png
Scientific Editor Work List	103839-scientific-editor-work-list.pdf
CrossCheck Report	103839-crosscheck-report.pdf