Publication Name	World Journal of Gastrointestinal Oncology
Manuscript ID	103843
Country	China

Received	2024-12-03 14:34
Peer-Review Started	2024-12-03 14:34
To Make the First Decision
Return for Revision	2025-01-03 08:50
Revised	2025-01-22 02:33
Second Decision	2025-02-17 02:42
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2025-02-17 07:45
Articles in Press	2025-02-17 07:45
Publication Fee Transferred	2025-01-26 08:14
Edit the Manuscript by Language Editor	2025-02-22 01:05
Typeset the Manuscript	2025-03-10 01:28
Publish the Manuscript Online	2025-03-25 16:19

ISSN	1948-5204 (online)
Open Access	This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
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Category	Oncology
Manuscript Type	Basic Study
Article Title	Nitric oxide synthase 1 inhibits progression of esophageal cancer through interacting with nitric oxide synthase 1 adaptor protein
Manuscript Source	Unsolicited Manuscript
All Author List	Zi-Wei Xiao, Ying-Chao Zeng, Lin-Tao Ji, Jia-Tao Yuan and Lin Li
ORCID	Author(s) ORCID Number Lin Li http://orcid.org/0009-0002-7763-4733
Funding Agency and Grant Number	Funding Agency Grant Number National Natural Science Foundation of China No. 81000201
Corresponding Author	Lin Li, Associate Professor, College of Medical, Hunan Normal University, No. 36 Lushan Road, Changsha 410081, Hunan Province, China. 18529482372@163.com
Key Words	Nitric oxide synthase 1; Nitric oxide synthase 1 adaptor protein; Autophagy; Phosphatidylinositol 3-kinase/protein kinase B pathway; Esophageal cancer
Core Tip	Nitric oxide synthase 1 (NOS1) inhibits the proliferation, metastasis, apoptosis, pyroptosis, and ferroptosis of esophageal cancer (ESCA) cells, enhances the autophagy, and effectively delays the onset of ESCA in a nude mouse xenograft model. Mechanistically, NOS1 interacts with the NOS1 adaptor protein, inhibiting the activation of the phosphatidylinositol 3-kinase/protein kinase B pathway. Both in vitro and in vivo studies suggest that NOS1 represents a potential therapeutic target for ESCA.
Publish Date	2025-03-25 16:19
Citation	<p>Xiao ZW, Zeng YC, Ji LT, Yuan JT, Li L. Nitric oxide synthase 1 inhibits progression of esophageal cancer through interacting with nitric oxide synthase 1 adaptor protein. <i>World J Gastrointest Oncol</i> 2025; 17(4): 103843</p>
URL	https://www.wjgnet.com/1948-5204/full/v17/i4/103843.htm
DOI	https://dx.doi.org/10.4251/wjgo.v17.i4.103843

Full Article (PDF)	WJGO-17-103843-with-cover.pdf
The ARRIVE Guidelines	103843-The-ARRIVE-Guidelines.pdf
Manuscript File	103843_Auto_Edited_023828.docx
Answering Reviewers	103843-answering-reviewers.pdf
Audio Core Tip	103843-audio.mp3
Biostatistics Review Certificate	103843-biostatistics-statement.pdf
Conflict-of-Interest Disclosure Form	103843-conflict-of-interest-statement.pdf
Copyright License Agreement	103843-copyright-assignment.pdf
Approved Grant Application Form(s) or Funding Agency Copy of any Approval Document(s)	103843-foundation-statement.pdf
Institutional Animal Care and Use Committee Approval Form or Document	103843-institutional-animal-care-and-use-committee-statement.pdf
Non-Native Speakers of English Editing Certificate	103843-non-native-speakers.pdf
Supplementary Material	103843-supplementary-material.pdf
Peer-review Report	103843-peer-reviews.pdf
Scientific Misconduct Check	103843-scientific-misconduct-check.png
Scientific Editor Work List	103843-scientific-editor-work-list.pdf
CrossCheck Report	103843-crosscheck-report.png
CrossCheck Report	103843-crosscheck-report.pdf