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Articles Published Processes
3/25/2025 4:19:19 PM | Browse: 108 | Download: 615
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Received |
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2024-12-03 14:34 |
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Peer-Review Started |
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2024-12-03 14:34 |
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First Decision by Editorial Office Director |
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2025-01-03 08:50 |
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Return for Revision |
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2025-01-03 08:50 |
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Revised |
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2025-01-22 02:33 |
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Publication Fee Transferred |
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2025-01-26 08:14 |
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Second Decision by Editor |
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2025-02-17 02:42 |
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Second Decision by Editor-in-Chief |
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Final Decision by Editorial Office Director |
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2025-02-17 07:45 |
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Articles in Press |
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2025-02-17 07:45 |
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Edit the Manuscript by Language Editor |
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2025-02-22 01:05 |
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Typeset the Manuscript |
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2025-03-10 01:28 |
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Publish the Manuscript Online |
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2025-03-25 16:19 |
| ISSN |
1948-5204 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2024. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
|
| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Oncology |
| Manuscript Type |
Basic Study |
| Article Title |
Nitric oxide synthase 1 inhibits progression of esophageal cancer through interacting with nitric oxide synthase 1 adaptor protein
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| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Zi-Wei Xiao, Ying-Chao Zeng, Lin-Tao Ji, Jia-Tao Yuan and Lin Li |
| ORCID |
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| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| National Natural Science Foundation of China |
No. 81000201 |
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| Corresponding Author |
Lin Li, Associate Professor, College of Medical, Hunan Normal University, No. 36 Lushan Road, Changsha 410081, Hunan Province, China. 18529482372@163.com |
| Key Words |
Nitric oxide synthase 1; Nitric oxide synthase 1 adaptor protein; Autophagy; Phosphatidylinositol 3-kinase/protein kinase B pathway; Esophageal cancer |
| Core Tip |
Nitric oxide synthase 1 (NOS1) inhibits the proliferation, metastasis, apoptosis, pyroptosis, and ferroptosis of esophageal cancer (ESCA) cells, enhances the autophagy, and effectively delays the onset of ESCA in a nude mouse xenograft model. Mechanistically, NOS1 interacts with the NOS1 adaptor protein, inhibiting the activation of the phosphatidylinositol 3-kinase/protein kinase B pathway. Both in vitro and in vivo studies suggest that NOS1 represents a potential therapeutic target for ESCA. |
| Publish Date |
2025-03-25 16:19 |
| Citation |
Xiao ZW, Zeng YC, Ji LT, Yuan JT, Li L. Nitric oxide synthase 1 inhibits progression of esophageal cancer through interacting with nitric oxide synthase 1 adaptor protein. World J Gastrointest Oncol 2025; 17(4): 103843 |
| URL |
https://www.wjgnet.com/1948-5204/full/v17/i4/103843.htm |
| DOI |
https://dx.doi.org/10.4251/wjgo.v17.i4.103843 |
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