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Articles Published Processes
6/20/2025 9:55:23 AM | Browse: 133 | Download: 684
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Received |
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2024-12-04 03:52 |
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Peer-Review Started |
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2024-12-04 03:52 |
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First Decision by Editorial Office Director |
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2025-03-19 23:20 |
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Return for Revision |
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2025-03-19 23:20 |
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Revised |
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2025-03-30 13:52 |
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Publication Fee Transferred |
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2025-04-03 11:38 |
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Second Decision by Editor |
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2025-05-30 02:43 |
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Second Decision by Editor-in-Chief |
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Final Decision by Editorial Office Director |
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2025-05-30 05:29 |
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Articles in Press |
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2025-05-30 05:29 |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2025-06-16 02:37 |
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Publish the Manuscript Online |
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2025-06-20 09:55 |
| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Neurosciences |
| Manuscript Type |
Basic Study |
| Article Title |
Endothelin A receptor in nociceptors is essential for persistent mechanical pain in a chronic pancreatitis of mouse model
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| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Bing Wang, Jia-Yi Ge, Jia-Ni Wu, Jia-Huan Xu, Xiao-Hua Cao, Na Chang, Xiang Zhou, Peng-Bo Jing, Xing-Jun Liu and Yong Wu |
| ORCID |
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| Funding Agency and Grant Number |
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| Corresponding Author |
Yong Wu, Chief Physician, MD, Department of Anesthesiology, The First People’s Hospital of Lianyungang, No. 6 Zhenhua East Street, Lianyungang 222000, Jiangsu Province, China. 18961325621@163.com |
| Key Words |
Chronic pancreatitis; Abdominal pain; Endothelin; Endothelin A receptor; Calcitonin gene-related peptide; Macrophage infiltration; Microglia activation |
| Core Tip |
Currently the mechanism underlying abdominal pain associated with chronic pancreatitis (CP) is not well understood. Utilizing dibutyltin dichloride-induced CP mouse model, it was found that the nociceptor-expressing endothelin A receptor (ETAR) is essential for the development of mechanical hypersensitivity following dibutyltin dichloride treatment. ETAR may contribute to this through regulating calcitonin gene-related peptide expression and activating immune cells. Therefore, targeting ETAR-dependent endothelin signaling in nociceptive sensory neurons may be a potential therapeutic approach for treating CP patients. |
| Publish Date |
2025-06-20 09:55 |
| Citation |
Wang B, Ge JY, Wu JN, Xu JH, Cao XH, Chang N, Zhou X, Jing PB, Liu XJ, Wu Y. Endothelin A receptor in nociceptors is essential for persistent mechanical pain in a chronic pancreatitis of mouse model. World J Gastroenterol 2025; 31(23): 103848 |
| URL |
https://www.wjgnet.com/1007-9327/full/v31/i23/103848.htm |
| DOI |
https://dx.doi.org/10.3748/wjg.v31.i23.103848 |
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