Publication Name	World Journal of Immunology
Manuscript ID	10385
Country	Japan

Received	2014-03-29 11:40
Peer-Review Started	2014-03-31 14:41
First Decision by Editorial Office Director
Return for Revision	2014-04-16 14:11
Revised	2014-05-14 21:09
Publication Fee Transferred
Second Decision by Editor	2014-09-10 09:14
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2014-09-10 09:45
Articles in Press	2014-09-10 09:45
Edit the Manuscript by Language Editor
Typeset the Manuscript	2014-11-11 16:39
Publish the Manuscript Online	2014-11-19 15:06

ISSN	2219-2824 (online)
Open Access
Copyright
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Website	http://www.wjgnet.com

Category	Allergy
Manuscript Type	Review
Article Title	Transgenic plants for allergen-specific immunotherapy
Manuscript Source	Invited Manuscript
All Author List	Tomoe Nishimura, Mayumi Saeki, Osamu Kaminuma, Fumio Takaiwa and Takachika Hiroi
Funding Agency and Grant Number	Funding Agency Grant Number Grant-in-Aid for Agri-health Project from the Ministry of Agriculture, Forestry and Fisheries of Japan (to Takaiwa F and Hiroi T) JSPS KAKENHI 24791817( to Saeki M) JSPS KAKENHI 26860122 (to Saeki M) JSPS KAKENHI 24500501 (to Kaminuma O) Grant-in-Aid of Mishima Kaiun Memorial Foundation (to Kaminuma O)
Corresponding Author	Takachika Hiroi, DDS, PhD, Allergy and Immunology Project, Tokyo Metropolitan Institute of Medical Science, 2-1-6, Kamikitazawa, Setagaya-ku, Tokyo 156-8506, Japan. hiroi-tk@igakuken.or.jp
Key Words	Allergic disease; Asthma; Oral immunotherapy; Rhinitis; Transgenic rice
Core Tip	We aim to establish clinically applicable oral immunotherapy (IT) by employing transgenic rice seeds (Tg rice) in which allergen epitopes are expressed. We have identified a suitable allergen packaging system, modified allergens to reduce their allergenicity, selected high allergen-producing lines, and evaluated their efficacy in allergic disease models. We are thus nearly ready to start clinical trials of our Tg rice for the treatment of Japanese cedar pollinosis.
Publish Date	2014-11-19 15:06
Citation	Nishimura T, Saeki M, Kaminuma O, Takaiwa F, Hiroi T. Transgenic plants for allergen-specific immunotherapy. World J Immunol 2014; 4(3): 141-148
URL	http://www.wjgnet.com/2219-2824/full/v4/i3/141.htm
DOI	http://dx.doi.org/10.5411/wji.v4.i3.141

Full Article (PDF)	WJI-4-141.pdf
Full Article (Word)	WJI-4-141.doc
Manuscript File	10385-Review.doc
Answering Reviewers	10385-Answering reviewers.pdf
Copyright License Agreement	10385-Copyright assignment.pdf
Non-Native Speakers of English Editing Certificate	10385-Language certificate.docx
Peer-review Report	10385-Peer review(s).pdf
Scientific Misconduct Check	10385-CrossCheck.jpg
Scientific Editor Work List	10385-Scientific editor work list.pdf