Publication Name	World Journal of Gastroenterology
Manuscript ID	10386
Country	Israel

Received	2014-03-29 11:44
Peer-Review Started	2014-03-29 14:10
First Decision by Editorial Office Director
Return for Revision	2014-04-24 13:46
Revised	2014-07-20 00:00
Publication Fee Transferred
Second Decision by Editor	2014-07-25 09:06
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2014-07-25 09:32
Articles in Press	2014-07-25 10:03
Edit the Manuscript by Language Editor	2014-11-13 19:05
Typeset the Manuscript	2014-12-22 20:24
Publish the Manuscript Online	2015-01-07 11:07

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access
Copyright
Article Reprints	For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions	For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher	Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website	http://www.wjgnet.com

Category	Gastroenterology & Hepatology
Manuscript Type	Retrospective Study
Article Title	Interferon therapy in hepatitis C leading to chronic type 1 diabetes
Manuscript Source	Unsolicited Manuscript
All Author List	Taiba Zornitzki, Stephen Malnick, Lyudmila Lysyy and Hilla Knobler
Funding Agency and Grant Number
Corresponding Author	Stephen Malnick, MA, MSc, MBBS, Director, Department of Gastroenterology, Hebrew University Medical School, Kaplan Medical Center, HaGalil St 5, Rehovot 76100, Israel. stephen@malnick.net
Key Words	Interferon; Hepatitis C; Type 1 diabetes; Autoimmune diseases; Pancreatic autoantibodies
Core Tip	Interferon (INF) treatment is an important component of hepatitis C virus treatment. Although INF-associated type 1 diabetes mellitus was described more than 2 decades ago its importance is under-recognized. Based on a review of all published cases we found that this complication typically appears abruptly, is manifested by severe hyperglycemia accompanied by a high titer of anti-islet antibodies and is often associated with autoimmune thyroid disease. Most worrisome, almost all patients who develop this complication require permanent insulin treatment. With the emergence of new interferon-free therapies, this serious complication has to be taken into consideration especially in relatively young patients with mild to moderate disease.
Publish Date	2015-01-07 11:07
Citation	Zornitzki T, Malnick S, Lysyy L, Knobler H. Interferon therapy in hepatitis C leading to chronic type 1 diabetes. World J Gastroenterol 2015; 21(1): 233-239
URL	http://www.wjgnet.com/1007-9327/full/v21/i1/233.htm
DOI	http://dx.doi.org/10.3748/wjg.v21.i1.233

Full Article (PDF)	WJG-21-233.pdf
Full Article (Word)	WJG-21-233.doc
Manuscript File	10386-Review.docx
Answering Reviewers	10386-Answering reviewers.pdf
Copyright License Agreement	10386-Copyright assignment.pdf
Peer-review Report	10386-Peer review.pdf
Scientific Misconduct Check	10386-CrossCheck.jpg
Scientific Editor Work List	10386-Scientific editor work list.pdf