Publication Name	World Journal of Gastroenterology
Manuscript ID	103892
Country	China

Received	2024-12-05 14:10
Peer-Review Started	2024-12-05 14:10
To Make the First Decision
Return for Revision	2025-01-22 05:08
Revised	2025-02-05 02:43
Second Decision	2025-03-26 02:37
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2025-03-26 06:00
Articles in Press	2025-03-26 06:00
Publication Fee Transferred	2025-02-07 02:08
Edit the Manuscript by Language Editor
Typeset the Manuscript	2025-04-07 03:29
Publish the Manuscript Online	2025-04-11 02:19

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access	This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
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Category	Gastroenterology & Hepatology
Manuscript Type	Prospective Study
Article Title	Efficacy of a novel artificial liver versatile plasma purification system in patients with acute-on-chronic liver failure
Manuscript Source	Unsolicited Manuscript
All Author List	Zhong-Shang Dai, Min Zhang, Yuan-Ye Deng, Ning Zhou and Yi Tian
ORCID	Author(s) ORCID Number Min Zhang http://orcid.org/0000-0002-2363-0393 Yi Tian http://orcid.org/0000-0002-1807-2817
Funding Agency and Grant Number	Funding Agency Grant Number Natural Science Foundation of Hunan Province, China 2022JJ30842 and 2024JJ6560 Clinical Medical Research Center for Viral Hepatitis of Hunan Province 2023SK4009 Beijing iGandan Foundation RGGJJ-2021-017 and iGandanF-1082022-RGG023
Corresponding Author	Yi Tian, MD, Department of Infectious Diseases, The Second Xiangya Hospital, Central South University, No. 139 Renmin Middle Road, Changsha 410011, Hunan Province, China. tianyi@csu.edu.cn
Key Words	Acute-on-chronic liver failure; Artificial liver support; Versatile plasma purification system; Re-hospitalization frequencies; Mortality
Core Tip	In this study, we introduced a novel artificial liver support model, termed the Versatile Plasma Purification System (VPPS), aimed at treating patients with acute-on-chronic liver failure (ACLF). We demonstrated that the VPPS significantly enhances liver function, coagulation parameters, and blood ammonia levels in ACLF patients, as evidenced by a comparative analysis of laboratory data obtained prior to and following treatment with both VPPS and Non-VPPS modes. Furthermore, our analysis revealed that patients receiving VPPS treatment exhibited reduced rates of readmission and mortality throughout the long-term follow-up period.
Publish Date	2025-04-11 02:19
Citation	<p>Dai ZS, Zhang M, Deng YY, Zhou N, Tian Y. Efficacy of a novel artificial liver versatile plasma purification system in patients with acute-on-chronic liver failure. <i>World J Gastroenterol</i> 2025; 31(14): 103892</p>
URL	https://www.wjgnet.com/1007-9327/full/v31/i14/103892.htm
DOI	https://dx.doi.org/10.3748/wjg.v31.i14.103892

Full Article (PDF)	WJG-31-103892-with-cover.pdf
CONSORT 2010 Statement	103892-CONSORT-2010-statement.pdf
Manuscript File	103892_Auto_Edited_060423.docx
Answering Reviewers	103892-answering-reviewers.pdf
Audio Core Tip	103892-audio.mp3
Biostatistics Review Certificate	103892-biostatistics-statement.pdf
Clinical Trial Registration Statement	103892-clinical-trial-registration-statement.pdf
Conflict-of-Interest Disclosure Form	103892-conflict-of-interest-statement.pdf
Copyright License Agreement	103892-copyright-assignment.pdf
Approved Grant Application Form(s) or Funding Agency Copy of any Approval Document(s)	103892-foundation-statement.pdf
Signed Informed Consent Form(s) or Document(s)	103892-informed-consent-statement.pdf
Institutional Review Board Approval Form or Document	103892-institutional-review-board-statement.pdf
Non-Native Speakers of English Editing Certificate	103892-non-native-speakers.pdf
Supplementary Material	103892-supplementary-material.pdf
Peer-review Report	103892-peer-reviews.pdf
Scientific Misconduct Check	103892-scientific-misconduct-check.png
Scientific Editor Work List	103892-scientific-editor-work-list.pdf
CrossCheck Report	103892-crosscheck-report.pdf