Publication Name	World Journal of Diabetes
Manuscript ID	103915
Country	China

Received	2024-12-04 08:57
Peer-Review Started	2024-12-09 01:57
To Make the First Decision
Return for Revision	2025-01-15 10:15
Revised	2025-01-26 13:20
Second Decision	2025-02-14 02:59
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2025-02-24 08:01
Articles in Press	2025-02-24 08:01
Publication Fee Transferred	2025-02-03 00:38
Edit the Manuscript by Language Editor
Typeset the Manuscript	2025-03-30 07:38
Publish the Manuscript Online	2025-04-25 07:53

ISSN	1948-9358 (online)
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Category	Pharmacology & Pharmacy
Manuscript Type	Basic Study
Article Title	Aucubin mitigates the elevation of microglial aerobic glycolysis and inflammation in diabetic neuropathic pain via aldose reductase
Manuscript Source	Unsolicited Manuscript
All Author List	Xue-Zhen Zheng, Hong-Yan Yu, Ye-Ru Chen and Jian-Sheng Fang
ORCID	Author(s) ORCID Number Xue-Zhen Zheng http://orcid.org/0009-0007-2045-9694 Ye-Ru Chen http://orcid.org/0000-0002-2457-7854
Funding Agency and Grant Number	Funding Agency Grant Number National Natural Science Foundation of China 82001424
Corresponding Author	Xue-Zhen Zheng, MD, Department of Anesthesiology, The First People's Hospital of Chun'an County, No. 1869 Huanhu North Road, Qiandaohu Town, Chun'an County, Hangzhou 311700, Zhejiang Province, China. zhengxuezhen2024@163.com
Key Words	Diabetic neuropathic pain; Aucubin; Glycolysis; Aldose reductase; Microglia
Core Tip	Our research demonstrates that Aucubin markedly reduces pain and anxiety-like behavior in Streptozotocin-induced diabetic mice. Furthermore, Aucubin reinstates microglial aerobic glycolysis and mitigates inflammation. Utilizing the SwissTargetPrediction database, we discovered 22 prospective protein targets for Aucubin concerning diabetic neuropathic pain (DNP). Analysis of protein-protein interaction networks and molecular docking experiments identified the potential role of aldose reductase (AKR1B1) to streptozotocin therapy. Aucubin does not repair aerobic glycolysis and inflammation in the setting of AKR1B1 depletion. The findings indicate that Aucubin could be a potential therapeutic drug for DNP, with AKR1B1 identified as a major target.
Publish Date	2025-04-25 07:53
Citation	<p>Zheng XZ, Yu HY, Chen YR, Fang JS. Aucubin mitigates the elevation of microglial aerobic glycolysis and inflammation in diabetic neuropathic pain via aldose reductase. <i>World J Diabetes</i> 2025; 16(5): 103915</p>
URL	https://www.wjgnet.com/1948-9358/full/v16/i5/103915.htm
DOI	https://dx.doi.org/10.4239/wjd.v16.i5.103915

Full Article (PDF)	WJD-16-103915-with-cover.pdf
The ARRIVE Guidelines	103915-The-ARRIVE-Guidelines.pdf
Manuscript File	103915_Auto_Edited_094028.docx
Answering Reviewers	103915-answering-reviewers.pdf
Audio Core Tip	103915-audio.m4a
Biostatistics Review Certificate	103915-biostatistics-statement.pdf
Conflict-of-Interest Disclosure Form	103915-conflict-of-interest-statement.pdf
Copyright License Agreement	103915-copyright-assignment.pdf
Approved Grant Application Form(s) or Funding Agency Copy of any Approval Document(s)	103915-foundation-statement.pdf
Institutional Animal Care and Use Committee Approval Form or Document	103915-institutional-animal-care-and-use-committee-statement.pdf
Non-Native Speakers of English Editing Certificate	103915-non-native-speakers.pdf
Supplementary Material	103915-supplementary-material.pdf
Peer-review Report	103915-peer-reviews.pdf
Journal Editor-in-Chief Review Report	103915-journal-editor-in-chief.pdf
Scientific Misconduct Check	103915-scientific-misconduct-check.png
Scientific Editor Work List	103915-scientific-editor-work-list.pdf
CrossCheck Report	103915-crosscheck-report.png
CrossCheck Report	103915-crosscheck-report.pdf