| ISSN |
1948-0210 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved. |
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| Permissions |
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Orthopedics |
| Manuscript Type |
Basic Study |
| Article Title |
Human umbilical cord mesenchymal stem cell-derived exosomal miR-199a-3p inhibits the MAPK4/NF-κB signaling pathway to relieve osteoarthritis
|
| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Ling-Qiang Chen, Sha Ma, Juan Yu, Da-Chen Zuo, Zi-Jing Yin, Fa-You Li, Xia He, Hai-Ting Peng, Xiao-Qing Shi, Wei-Juan Huang, Qin Li and Jing Wang |
| ORCID |
|
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| Basic Research Plan of Yunnan Province |
202201AT070059 |
| National Natural Science Foundation of China |
81760407 |
| Science and Technology Talent and Platform Plan of Yunnan Provincial Department of Science and Technology |
202205AC160066 |
|
| Corresponding Author |
Jing Wang, Department of Rheumatology, The First People’s Hospital of Yunnan Province, The Affiliated Hospital of Kunming University of Science and Technology, No. 157 Jinbi Road, Xishan District, Kunming 650032, Yunnan Province, China. wangjing201456@163.com |
| Key Words |
Osteoarthritis; Human umbilical cord mesenchymal stem cells; Exosomes; MiR-199a-3p; Mitogen-activated protein kinase 4; Nuclear factor-kappaB |
| Core Tip |
Osteoarthritis (OA), a debilitating joint disorder, currently lacks effective treatment options. This study reveals that exosomal miR-199a-3p derived from human umbilical cord mesenchymal stem cells offers a novel therapeutic strategy for OA. By targeting the mitogen-activated protein kinase 4/nuclear factor-kappaB signaling pathway, miR-199a-3p significantly reduces inflammation and inhibits apoptosis in chondrocytes. These findings highlight the potential of exosomal miR-199a-3p delivery as a promising approach for managing OA, providing a foundation for future clinical applications. |
| Publish Date |
2025-04-23 03:33 |
| Citation |
<p>Chen LQ, Ma S, Yu J, Zuo DC, Yin ZJ, Li FY, He X, Peng HT, Shi XQ, Huang WJ, Li Q, Wang J. Human umbilical cord mesenchymal stem cell-derived exosomal miR-199a-3p inhibits the MAPK4/NF-κB signaling pathway to relieve osteoarthritis. <i>World J Stem Cells</i> 2025; 17(4): 103919</p> |
| URL |
https://www.wjgnet.com/1948-0210/full/v17/i4/103919.htm |
| DOI |
https://dx.doi.org/10.4252/wjsc.v17.i4.103919 |
