| ISSN |
2220-315x (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
|
| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
|
| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Endocrinology & Metabolism |
| Manuscript Type |
Basic Study |
| Article Title |
PI3K/AKT/GSK3β regulatory axis in bone mesenchymal stem cells initiates diabetic myocardial infarction via miR-142-3p
|
| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Ning Gao, Peng-Fei Wu, Ming-Wen Wu, Yu-Meng Li, Xu Liang, Fei-Fei Wang, Xue-Jing Li, Qing-Qing Shen, Tian-Peng Zheng, Xiao-Ling Liu, Yi Sun and Liu-Xue Yang |
| ORCID |
|
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| Health Commission Project |
Z2014334 |
| Natural Science Foundation of Guangxi Province, China |
2020GXNSFAA238036 |
|
| Corresponding Author |
Yi Sun, Department of Toxicology, Guilin Medical University, No. 1, Zhiyuan Road, Lingui District, Guilin City, Guangxi Zhuang Autonomous Region, Guilin 541004, Guangxi Zhuang Autonomous Region, China. sunyide163@163.com |
| Key Words |
Ferroptosis; Liraglutide; MiR-142-3p; Myocardial infarction in diabetes; Bones mesenchymal stem cells |
| Core Tip |
This study demonstrated that using bones mesenchymal stem cells (BMCs) as an intervention can simultaneously reduce blood sugar levels and promote hypoxic myocardial recovery. However, when miR-142-3p expression in BMCs was low, there was a reduced therapeutic efficacy of BMCs and activation of PI3K/AKT/GSK-3β. The regulatory axis regulates changes in the protein expression levels of the ferroptosis-related genes GPX4/CHCHD6. These findings suggest that miR-142-3p via the PI3K/AKT/GSK-3β regulation axis that jointly inhibits ferroptosis, may be one of the therapeutic mechanisms of BMCs in diabetic myocardial infarction. |
| Publish Date |
2025-08-12 08:18 |
| Citation |
<p>Gao N, Wu PF, Wu MW, Li YM, Liang X, Wang FF, Li XJ, Shen QQ, Zheng TP, Liu XL, Sun Y, Yang LX. PI3K/AKT/GSK3β regulatory axis in bone mesenchymal stem cells initiates diabetic myocardial infarction via miR-142-3p. <i>World J Exp Med</i> 2025; 15(3): 103948</p> |
| URL |
https://www.wjgnet.com/2220-315X/full/v15/i3/103948.htm |
| DOI |
https://dx.doi.org/10.5493/wjem.v15.i3.103948 |
