Publication Name	World Journal of Gastroenterology
Manuscript ID	103952
Country	United States

Received	2024-12-05 13:35
Peer-Review Started	2024-12-05 13:35
To Make the First Decision
Return for Revision	2025-01-14 05:11
Revised	2025-01-26 05:35
Second Decision	2025-03-03 02:41
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2025-03-03 05:19
Articles in Press	2025-03-03 05:19
Publication Fee Transferred	2025-01-31 17:53
Edit the Manuscript by Language Editor
Typeset the Manuscript	2025-03-13 08:29
Publish the Manuscript Online	2025-03-26 08:40

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access	This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Copyright	© The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved.
Article Reprints	For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions	For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher	Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website	http://www.wjgnet.com

Category	Gastroenterology & Hepatology
Manuscript Type	Basic Study
Article Title	Characterization of hepatic pathology during azoxymethane-induced acute liver failure
Manuscript Source	Unsolicited Manuscript
All Author List	Shadikchhya Maya Bhattarai, Ashwin Jhawer, Gabriel Frampton, Eleonora Troyanovskaya, Sharon DeMorrow and Matthew McMillin
ORCID	Author(s) ORCID Number Matthew McMillin http://orcid.org/0000-0002-5980-0921
Funding Agency and Grant Number	Funding Agency Grant Number The Department of Veterans Affairs Biomedical Laboratory Research & Development Service Award BX003486 National Institutes of Health Awards R01DK112803 and R01DK135995
Corresponding Author	Matthew McMillin, Assistant Professor, PhD, Huffington Department of Education, Baylor College of Medicine, 702 SW HK Dodgen Loop, Temple, TX 76548, United States. matthew.mcmillin@bcm.edu
Key Words	Acute liver failure; Azoxymethane; Apoptosis; Necrosis; Senescence
Core Tip	The azoxymethane (AOM) model of liver injury is used as a toxin-induced model to study acute liver failure and the development of hepatic encephalopathy (HE). After initial characterization of the liver injury in this model, little research has been performed to understand the specific cellular and molecular mechanisms of hepatic injury, with most studies focusing on neurological changes associated with HE. Here, we identify that the AOM model is associated with hepatic inflammation and oxidative stress that progresses to apoptosis, necrosis and hepatocellular senescence. These findings provide additional insight into this model and will help determine which components of hepatic pathology to investigate when therapeutic approaches are employed.
Publish Date	2025-03-26 08:40
Citation	<p>Bhattarai SM, Jhawer A, Frampton G, Troyanovskaya E, DeMorrow S, McMillin M. Characterization of hepatic pathology during azoxymethane-induced acute liver failure. <i>World J Gastroenterol</i> 2025; 31(12): 103952</p>
URL	https://www.wjgnet.com/1007-9327/full/v31/i12/103952.htm
DOI	https://dx.doi.org/10.3748/wjg.v31.i12.103952

Full Article (PDF)	WJG-31-103952-with-cover.pdf
The ARRIVE Guidelines	103952-The-ARRIVE-Guidelines.pdf
Manuscript File	103952_Auto_Edited_073807.docx
Answering Reviewers	103952-answering-reviewers.pdf
Audio Core Tip	103952-audio.m4a
Biostatistics Review Certificate	103952-biostatistics-statement.pdf
Conflict-of-Interest Disclosure Form	103952-conflict-of-interest-statement.pdf
Copyright License Agreement	103952-copyright-assignment.pdf
Approved Grant Application Form(s) or Funding Agency Copy of any Approval Document(s)	103952-foundation-statement.pdf
Institutional Animal Care and Use Committee Approval Form or Document	103952-institutional-animal-care-and-use-committee-statement.pdf
Supplementary Material	103952-supplementary-material.pdf
Peer-review Report	103952-peer-reviews.pdf
Scientific Misconduct Check	103952-scientific-misconduct-check.png
Scientific Editor Work List	103952-scientific-editor-work-list.pdf
CrossCheck Report	103952-crosscheck-report.pdf