Publication Name	World Journal of Gastroenterology
Manuscript ID	103991
Country	China

Received	2024-12-09 08:43
Peer-Review Started	2024-12-09 08:43
To Make the First Decision
Return for Revision	2025-01-18 01:29
Revised	2025-01-26 07:29
Second Decision	2025-02-24 02:40
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2025-02-24 05:43
Articles in Press	2025-02-24 05:43
Publication Fee Transferred	2025-01-27 01:41
Edit the Manuscript by Language Editor
Typeset the Manuscript	2025-03-17 03:09
Publish the Manuscript Online	2025-03-26 08:40

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access	This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
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Category	Medicine, General & Internal
Manuscript Type	Basic Study
Article Title	Increased keratin 80 expression predicts poor prognosis and promotes oxaliplatin resistance in gastric cancer
Manuscript Source	Unsolicited Manuscript
All Author List	Bo Yang, Hong-Xia Cao, Ya-Wei He, Ji-Jie Ouyang, Meng Lv, Yong-Xiang Li and Yi-Da Lu
ORCID	Author(s) ORCID Number Bo Yang http://orcid.org/0000-0003-1829-3924 Yi-Da Lu http://orcid.org/0000-0003-3764-2720
Funding Agency and Grant Number	Funding Agency Grant Number National Natural Science Foundation of China 874063
Corresponding Author	Yi-Da Lu, Department of General Surgery, The Second Affiliated Hospital of Anhui Medical University, No. 678 Furong Road, Hefei 230601, Anhui Province, China. luyida66@163.com
Key Words	Keratin 80; Gastric cancer; Oxaliplatin; Elongation factor 1-alpha 1; Gastrointestinal tract; Signaling pathway
Core Tip	In this paper, keratin 80 (KRT80) was found to be overexpressed in gastric cancer (GC) tissues, functioning as an oncogene and correlating with poor patient prognosis. KRT80 promoted GC proliferation, migration, invasion abilities and oxaliplatin resistance by activating the NF-κB signaling pathway. Immunoprecipitation and mass spectrometry analyses identified elongation factor 1-alpha 1 (EEF1A1) as a binding protein of KRT80, enhancing its protein stability. Notably, knockdown of EEF1A1 partially reversed the effects of KRT80 overexpression in GC cells.
Publish Date	2025-03-26 08:40
Citation	<p>Yang B, Cao HX, He YW, Ouyang JJ, Lv M, Li YX, Lu YD. Increased keratin 80 expression predicts poor prognosis and promotes oxaliplatin resistance in gastric cancer. <i>World J Gastroenterol</i> 2025; 31(12): 103991</p>
URL	https://www.wjgnet.com/1007-9327/full/v31/i12/103991.htm
DOI	https://dx.doi.org/10.3748/wjg.v31.i12.103991

Full Article (PDF)	WJG-31-103991-with-cover.pdf
The ARRIVE Guidelines	103991-The-ARRIVE-Guidelines.pdf
Manuscript File	103991_Auto_Edited_090347.docx
Answering Reviewers	103991-answering-reviewers.pdf
Audio Core Tip	103991-audio.mp3
Biostatistics Review Certificate	103991-biostatistics-statement.pdf
Conflict-of-Interest Disclosure Form	103991-conflict-of-interest-statement.pdf
Copyright License Agreement	103991-copyright-assignment.pdf
Approved Grant Application Form(s) or Funding Agency Copy of any Approval Document(s)	103991-foundation-statement.pdf
Institutional Animal Care and Use Committee Approval Form or Document	103991-institutional-animal-care-and-use-committee-statement.pdf
Institutional Review Board Approval Form or Document	103991-institutional-review-board-statement.pdf
Non-Native Speakers of English Editing Certificate	103991-non-native-speakers.pdf
Peer-review Report	103991-peer-reviews.pdf
Scientific Misconduct Check	103991-scientific-misconduct-check.png
Scientific Editor Work List	103991-scientific-editor-work-list.pdf
CrossCheck Report	103991-crosscheck-report.pdf