Publication Name	World Journal of Diabetes
Manuscript ID	104007
Country	China

Received	2024-12-09 07:09
Peer-Review Started	2024-12-10 01:14
To Make the First Decision
Return for Revision	2025-01-12 07:10
Revised	2025-01-21 11:57
Second Decision	2025-02-10 02:33
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2025-02-10 06:39
Articles in Press	2025-02-10 06:39
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2025-02-21 01:53
Publish the Manuscript Online	2025-02-28 10:47

ISSN	1948-9358 (online)
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Category	Biochemistry & Molecular Biology
Manuscript Type	Letter to the Editor
Article Title	Double-edged sword of L-arginine in diabetes: Exploring anti-inflammatory and antioxidant strategies
Manuscript Source	Invited Manuscript
All Author List	Shuai Liu, Ning Li, Jia-Jia Jin and Yong-Wei Yu
ORCID	Author(s) ORCID Number Shuai Liu http://orcid.org/0009-0009-6551-0224 Yong-Wei Yu http://orcid.org/0000-0001-8319-7707
Funding Agency and Grant Number
Corresponding Author	Yong-Wei Yu, Assistant Professor, Intensive Care Unit, The First Affiliated Hospital, Zhejiang University School of Medicine, No. 79 Qingchun Road, Shangcheng District, Hangzhou 310003, Zhejiang Province, China. yuyongwei@zju.edu.cn
Key Words	L-arginine; Diabetic cardiomyopathy; Oxidative stress; Nuclear factor erythroid 2-related factor 2; Nitric oxide synthase
Core Tip	L-arginine (L-Arg) exhibits dose-dependent effects in diabetic cardiomyopathy, with low doses improving lipid profiles and high doses exacerbating oxidative stress and inflammation. This letter emphasizes the need for targeted interventions, such as nuclear factor erythroid 2-related factor 2 activation, nitric oxide synthase modulation, and combination therapies, to mitigate these adverse effects and enhance L-Arg’s clinical safety, offering safer therapeutic options for diabetic patients at risk of cardiovascular complications.
Publish Date	2025-02-28 10:47
Citation	<p>Liu S, Li N, Jin JJ, Yu YW. Double-edged sword of L-arginine in diabetes: Exploring anti-inflammatory and antioxidant strategies. <i>World J Diabetes</i> 2025; 16(4): 104007</p>
URL	https://www.wjgnet.com/1948-9358/full/v16/i4/104007.htm
DOI	https://dx.doi.org/10.4239/wjd.v16.i4.104007

Full Article (PDF)	WJD-16-104007-with-cover.pdf
Manuscript File	104007_Auto_Edited_054901.docx
Answering Reviewers	104007-answering-reviewers.pdf
Audio Core Tip	104007-audio.mp3
Conflict-of-Interest Disclosure Form	104007-conflict-of-interest-statement.pdf
Copyright License Agreement	104007-copyright-assignment.pdf
Non-Native Speakers of English Editing Certificate	104007-non-native-speakers.pdf
Peer-review Report	104007-peer-reviews.pdf
Scientific Misconduct Check	104007-scientific-misconduct-check.png
Scientific Editor Work List	104007-scientific-editor-work-list.pdf
CrossCheck Report	104007-crosscheck-report.png
CrossCheck Report	104007-crosscheck-report.pdf