Publication Name	World Journal of Gastroenterology
Manuscript ID	10401
Country	Germany

Received	2014-03-29 21:09
Peer-Review Started	2014-03-30 13:17
To Make the First Decision	2014-04-15 20:00
Return for Revision	2014-04-23 19:25
Revised	2014-05-03 04:58
Second Decision	2014-07-25 09:06
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2014-07-25 09:32
Articles in Press	2014-07-25 10:03
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2014-12-02 16:41
Publish the Manuscript Online	2014-12-18 17:08

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access
Copyright
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Publisher	Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website	http://www.wjgnet.com

Category	Oncology
Manuscript Type	Clinical Trials Study
Article Title	Genomic landscape of pancreatic neuroendocrine tumors
Manuscript Source	Unsolicited Manuscript
All Author List	Niklas Gebauer, Christian Schmidt-Werthern, Veronica Bernard, Alfred C Feller, Tobias Keck, Nehara Begum, Dirk Rades, Hendrik Lehnert, Georg Brabant and Christoph Thorns
Funding Agency and Grant Number	Funding Agency Grant Number IPSEN Pharma GmbH (Ettlingen), Germany Novartis Pharma GmbH, Nürnberg, Germany
Corresponding Author	Niklas Gebauer, MD, Department of Pathology, University Hospital of Schleswig-Holstein, Campus Lübeck, Ratzenburger Allee 160, 23538 Luebeck, Germany. niklas.gebauer@medizin.uni-luebeck.de
Key Words	Array comparative genomic hybridization; Copy number alterations; Chromosomal aberrations; Pancreatic neuroendocrine tumors; Prognosis
Core Tip	In the current study, we characterized the genomic landscape of pancreatic neuroendocrine tumors (PanNETs). Analysis of recurrent genomic amplifications delineated two independent clusters of genomic aberrations as well as two patient groups characterized by significantly overlapping cytogenetic features. Copy number alterations affecting chromosomes 6, 8, 9 and 17 were shown to be associated with survival. A high degree of genomic heterogeneity between primary tumor samples and metastatic lesions demonstrates the need for a more focused molecular and cytogenetic characterization in the light of upcoming targeted therapy approaches. PanNETs appear to be genetically distinct from other types of neuroendocrine tumors.
Publish Date	2014-12-18 17:08
Citation	Gebauer N, Schmidt-Werthern C, Bernard V, Feller AC, Keck T, Begum N, Rades D, Lehnert H, Brabant G, Thorns C. Genomic landscape of pancreatic neuroendocrine tumors. World J Gastroenterol 2014; 20(46): 17498-17506
URL	http://www.wjgnet.com/1007-9327/full/v20/i46/17498.htm
DOI	http://dx.doi.org/10.3748/wjg.v20.i46.17498

Full Article (PDF)	WJG-20-17498.pdf
Full Article (Word)	WJG-20-17498.doc
Manuscript File	10401-Review.doc
Answering Reviewers	10401-Answering reviewers.pdf
Copyright License Agreement	10401-Copyright assignment.pdf
Peer-review Report	10401-Peer reviews.pdf
Scientific Misconduct Check	10401-CrossCheck.jpg
Scientific Editor Work List	10401-Scientific editor work list.pdf