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Articles Published Processes
3/13/2025 10:11:02 AM | Browse: 31 | Download: 38
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Received |
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2024-12-09 04:13 |
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Peer-Review Started |
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2024-12-09 04:13 |
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To Make the First Decision |
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Return for Revision |
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2025-01-03 21:41 |
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Revised |
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2025-01-16 14:53 |
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Second Decision |
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2025-02-17 02:42 |
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Accepted by Journal Editor-in-Chief |
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Accepted by Executive Editor-in-Chief |
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2025-02-17 05:01 |
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Articles in Press |
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2025-02-17 05:01 |
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Publication Fee Transferred |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2025-03-05 02:38 |
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Publish the Manuscript Online |
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2025-03-13 10:11 |
| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Letter to the Editor |
| Article Title |
Impact of poorly controlled type II diabetes mellitus on chemoresistance in colorectal cancer
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| Manuscript Source |
Invited Manuscript |
| All Author List |
Aditya Gaur, Rick Maity, Arkadeep Dhali and Jyotirmoy Biswas |
| ORCID |
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| Funding Agency and Grant Number |
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| Corresponding Author |
Arkadeep Dhali, Academic Unit of Gastroenterology, Sheffield Teaching Hospitals NHS Foundation Trust, Royal Hallamshire Hospital, Glossop Road, Sheffield S10 2JF, United Kingdom. arkadipdhali@gmail.com |
| Key Words |
Type 2 diabetes mellitus; Colorectal cancer; Cancer; Chemoresistance; Diabetes mellitus; Hyperglycemia; Chemotherapy |
| Core Tip |
Type 2 diabetes mellitus exacerbates colorectal cancer (CRC) progression by inducing chemoresistance through mechanisms such as oxidative stress, altered metabolic pathways, and disrupted apoptotic signalling. Poor glycemic control worsens patient outcomes, reducing disease-free survival and overall survival. Antidiabetic treatments, notably metformin, show potential in enhancing chemotherapy efficacy while improving glycemic management. A multidisciplinary care model involving oncologists, endocrinologists, and surgeons is essential to mitigate chemoresistance and optimize survival outcomes in CRC patients with type 2 diabetes mellitus. Prioritizing glycemic control through integrated therapeutic strategies offers a promising avenue for improving CRC treatment success in this high-risk patient population. |
| Publish Date |
2025-03-13 10:11 |
| Citation |
<p>Gaur A, Maity R, Dhali A, Biswas J. Impact of poorly controlled type II diabetes mellitus on chemoresistance in colorectal cancer. <i>World J Gastroenterol</i> 2025; 31(11): 104065</p> |
| URL |
https://www.wjgnet.com/1007-9327/full/v31/i11/104065.htm |
| DOI |
https://dx.doi.org/10.3748/wjg.v31.i11.104065 |
© 2004-2025 Baishideng Publishing Group Inc. All rights reserved. 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
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