| ISSN |
1948-5182 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Rheumatology |
| Manuscript Type |
Basic Study |
| Article Title |
Effect of rapamycin nanoparticles in an animal model of primary biliary cholangitis
|
| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Yu-Shu Yang, Xian-Rui Li, Zhi-Min Wang, Lin Zheng, Jin-Long Li, Xiao-Lin Cui, Yan-Biao Song, Jun-Ji Ma, Hui-Fang Guo, Li-Xia Gao and Xiao-Hui Zhou |
| ORCID |
|
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| Cultivation Project of Hebei Natural Science Foundation-Precision Medicine Joint Fund |
No. H2021206239 |
|
| Corresponding Author |
Li-Xia Gao, Chief Physician, MD, PhD, Professor, Department of Rheumatology and Immunology, The Second Hospital of Hebei Medical University, No. 215 Heping West Road, Shijiazhuang 050000, Hebei Province, China. 27100287@hebmu.edu.cn |
| Key Words |
Primary biliary cholangitis; Rapamycin; Nanoparticles; Mouse model; Anti-mitochondrial antibodies; Cytokine |
| Core Tip |
Primary biliary cholangitis (PBC) is a chronic autoimmune-mediated cholestatic liver disease, which can gradually progress to liver fibrosis, cirrhosis. The global incidence of PBC has been increasing year by year in recent decades. But there are few effective drugs, the effect of nanoparticles encapsulating rapamycin on the treatment of PBC using an animal model is examined in this paper, targeting at new approaches for the treatment of PBC. |
| Publish Date |
2025-06-26 07:27 |
| Citation |
<p>Yang YS, Li XR, Wang ZM, Zheng L, Li JL, Cui XL, Song YB, Ma JJ, Guo HF, Gao LX, Zhou XH. Effect of rapamycin nanoparticles in an animal model of primary biliary cholangitis. <i>World J Hepatol</i> 2025; 17(6): 104073</p> |
| URL |
https://www.wjgnet.com/1948-5182/full/v17/i6/104073.htm |
| DOI |
https://dx.doi.org/10.4254/wjh.v17.i6.104073 |
