Publication Name	World Journal of Gastroenterology
Manuscript ID	104117
Country	China

Received	2024-12-11 08:54
Peer-Review Started	2024-12-11 08:54
To Make the First Decision
Return for Revision	2025-02-08 23:20
Revised	2025-02-21 09:20
Second Decision	2025-03-20 02:37
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2025-03-21 06:41
Articles in Press	2025-03-21 06:41
Publication Fee Transferred	2025-02-24 08:18
Edit the Manuscript by Language Editor
Typeset the Manuscript	2025-04-07 03:31
Publish the Manuscript Online	2025-04-11 02:19

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access	This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Copyright	© The Author(s) 2024. Published by Baishideng Publishing Group Inc. All rights reserved.
Article Reprints	For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions	For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher	Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website	http://www.wjgnet.com

Category	Gastroenterology & Hepatology
Manuscript Type	Basic Study
Article Title	Hepatic-specific vitamin D receptor downregulation alleviates aging-related metabolic dysfunction-associated steatotic liver disease
Manuscript Source	Unsolicited Manuscript
All Author List	Feng Zhu, Bing-Ru Lin, Shi-Hua Lin, Chao-Hui Yu and Yun-Mei Yang
ORCID	Author(s) ORCID Number Feng Zhu http://orcid.org/0000-0003-4854-9791 Chao-Hui Yu http://orcid.org/0000-0003-4842-3646 Yun-Mei Yang http://orcid.org/0000-0002-9086-6101
Funding Agency and Grant Number	Funding Agency Grant Number National Natural Science Foundation of China No. 820300089
Corresponding Author	Chao-Hui Yu, Chief Physician, PhD, Professor, Department of Gastroenterology, The First Affiliated Hospital, School of Medicine, Zhejiang University, No. 79 Qingchun Road, Hangzhou 310003, Zhejiang Province, China. zyyyych@zju.edu.cn
Key Words	Aging; Metabolic dysfunction-associated steatotic liver disease; Vitamin D receptor; Steatosis; Hepatocytes
Core Tip	We showed that aging exacerbated the pathogenesis of metabolic dysfunction-associated steatotic liver disease. Hepatic-specific knockdown of vitamin D receptor alleviated the progression of aging-related metabolic dysfunction-associated steatotic liver disease. Vitamin D receptor is a crucial factor implicated in steatosis.
Publish Date	2025-04-11 02:19
Citation	<p>Zhu F, Lin BR, Lin SH, Yu CH, Yang YM. Hepatic-specific vitamin D receptor downregulation alleviates aging-related metabolic dysfunction-associated steatotic liver disease. <i>World J Gastroenterol</i> 2025; 31(14): 104117</p>
URL	https://www.wjgnet.com/1007-9327/full/v31/i14/104117.htm
DOI	https://dx.doi.org/10.3748/wjg.v31.i14.104117

Full Article (PDF)	WJG-31-104117-with-cover.pdf
The ARRIVE Guidelines	104117-The-ARRIVE-Guidelines.pdf
Manuscript File	104117_Auto_Edited_075911.docx
Answering Reviewers	104117-answering-reviewers.pdf
Audio Core Tip	104117-audio.m4a
Biostatistics Review Certificate	104117-biostatistics-statement.pdf
Conflict-of-Interest Disclosure Form	104117-conflict-of-interest-statement.pdf
Copyright License Agreement	104117-copyright-assignment.pdf
Approved Grant Application Form(s) or Funding Agency Copy of any Approval Document(s)	104117-foundation-statement.pdf
Institutional Animal Care and Use Committee Approval Form or Document	104117-institutional-animal-care-and-use-committee-statement.pdf
Non-Native Speakers of English Editing Certificate	104117-non-native-speakers.pdf
Supplementary Material	104117-supplementary-material.pdf
Peer-review Report	104117-peer-reviews.pdf
Scientific Misconduct Check	104117-scientific-misconduct-check.png
Scientific Editor Work List	104117-scientific-editor-work-list.pdf
CrossCheck Report	104117-crosscheck-report.png
CrossCheck Report	104117-crosscheck-report.pdf