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Articles Published Processes
5/20/2025 3:37:34 AM | Browse: 9 | Download: 33
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Received |
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2024-12-23 02:55 |
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Peer-Review Started |
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2024-12-23 02:55 |
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To Make the First Decision |
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Return for Revision |
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2025-01-16 13:29 |
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Revised |
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2025-02-21 00:24 |
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Second Decision |
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2025-04-15 02:38 |
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Accepted by Journal Editor-in-Chief |
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Accepted by Executive Editor-in-Chief |
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2025-04-15 08:45 |
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Articles in Press |
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2025-04-15 08:45 |
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Publication Fee Transferred |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2025-05-08 00:58 |
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Publish the Manuscript Online |
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2025-05-20 03:37 |
| ISSN |
2218-4333 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Oncology |
| Manuscript Type |
Basic Study |
| Article Title |
Functional heterogeneity and clinical implications of CD4+ T cell subtypes in high-grade serous ovarian carcinoma
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| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Bei-Lei Zhang, Wei Gao, Ling He, Xiao-Ting Liu, Zhong-Ming Wang and Li Tan |
| ORCID |
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| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| Natural Science Foundation of Hunan Province, China |
2022JJ30329 |
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| Corresponding Author |
Li Tan, Associate Professor, Chief Physician, MD, Department of Obstetrics and Gynecology, The Second People's Hospital of Hunan Province (Brain Hospital of Hunan Province), No. 427, Section 3, Furong Middle Road, Changsha City, Changsha 410007, Hunan Province, China. tanli2022@163.com |
| Key Words |
High-grade serous ovarian carcinoma; CD4+ T cells; Regulatory T cells; Immune microenvironment; Single-cell RNA sequencing |
| Core Tip |
This study uncovers the functional heterogeneity of CD4+ T cell subtypes in high-grade serous ovarian carcinoma (HGSOC), revealing their tissue-specific distributions and roles within the tumor microenvironment. Regulatory T cells (Tregs), particularly Treg3 cells, were identified as key immunosuppressive players enriched in adnexal tissues, correlating with poor prognosis and reduced immunotherapy response. By integrating single-cell RNA sequencing data, we provide novel insights into immune evasion mechanisms and identify Treg3 cells as potential therapeutic targets. These findings advance our understanding of HGSOC immunity and offer pathways for developing personalized immunotherapies. |
| Publish Date |
2025-05-20 03:37 |
| Citation |
<p>Zhang BL, Gao W, He L, Liu XT, Wang ZM, Tan L. Functional heterogeneity and clinical implications of CD4+ T cell subtypes in high-grade serous ovarian carcinoma. <i>World J Clin Oncol</i> 2025; 16(5): 104138</p> |
| URL |
https://www.wjgnet.com/2218-4333/full/v16/i5/104138.htm |
| DOI |
https://dx.doi.org/10.5306/wjco.v16.i5.104138 |
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