| ISSN |
2218-4333 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved. |
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Medicine, Research & Experimental |
| Manuscript Type |
Basic Study |
| Article Title |
Role of cell cycle-related gene SAC3 domain containing 1 as a potential target of nitidine chloride in hepatocellular carcinoma progression
|
| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Qing-Ling Huang, Sheng-Sheng Zhou, Jian-Di Li, Dan-Dan Xiong, Rong-Quan He, Zhi-Guang Huang, Lei Wang, Tian-Ming Tan, Yi-Wu Dang, Wei-Jia Mo, Zhen-Bo Feng, Gang Chen and Zhen-Dong Yang |
| ORCID |
|
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| National Natural Science Foundation of China |
No. 82160762 |
| National Natural Science Foundation of China |
No. 82460783 |
| Guangxi Medical University “Four New” Project |
No. SX202403 |
| Innovation Project of Guangxi Graduate Education |
No. JGY2023068 |
| Guangxi Higher Education Undergraduate Teaching Reform Project |
No. 2022JGA146 |
| China Undergraduate Innovation and Entrepreneurship Training Program |
No. 202310598045 |
|
| Corresponding Author |
Zhen-Dong Yang, Department of Radiation Oncology, The First Affiliated Hospital of Guangxi Medical University, No. 6 Shuangyong Road, Nanning 530021, Guangxi Zhuang Autonomous Region, China. yangzhendong@stu.gxmu.edu.cn |
| Key Words |
Hepatocellular carcinoma; SAC3 domain containing 1; Nitidine chloride; Cell cycle; Molecular docking |
| Core Tip |
The role of SAC3 domain containing 1 (SAC3D1) in hepatocellular carcinoma (HCC) remains unclear. Through bioinformatic analysis, molecular docking techniques, and in vitro experiments, this study demonstrates for the first time that SAC3D1 serves as a novel target for nitidine chloride (NC), which previous studies have shown to have anti-HCC effects. Downregulation of SAC3D1 by NC may inhibit HCC progression by regulating the cell cycle, providing opportunities for novel therapeutic approaches in HCC treatment. |
| Publish Date |
2025-05-20 03:37 |
| Citation |
<p>Huang QL, Zhou SS, Li JD, Xiong DD, He RQ, Huang ZG, Wang L, Tan TM, Dang YW, Mo WJ, Feng ZB, Chen G, Yang ZD. Role of cell cycle-related gene SAC3 domain containing 1 as a potential target of nitidine chloride in hepatocellular carcinoma progression. <i>World J Clin Oncol</i> 2025; 16(5): 104154</p> |
| URL |
https://www.wjgnet.com/2218-4333/full/v16/i5/104154.htm |
| DOI |
https://dx.doi.org/10.5306/wjco.v16.i5.104154 |
