Publication Name	World Journal of Gastroenterology
Manuscript ID	10417
Country	Australia

Received	2014-03-31 09:41
Peer-Review Started	2014-03-31 17:46
First Decision by Editorial Office Director
Return for Revision	2014-06-15 13:48
Revised	2014-06-26 14:33
Publication Fee Transferred
Second Decision by Editor	2014-08-28 09:48
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2014-08-28 10:05
Articles in Press	2014-08-28 10:48
Edit the Manuscript by Language Editor
Typeset the Manuscript	2014-11-16 12:48
Publish the Manuscript Online	2014-12-02 10:46

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access
Copyright
Article Reprints	For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions	For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher	Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website	http://www.wjgnet.com

Category	Microbiology
Manuscript Type	Topic Highlights
Article Title	Mechanistic links between gut microbial community dynamics, microbial functions and metabolic health
Manuscript Source	Invited Manuscript
All Author List	Connie WY Ha, Yan Y Lam and Andrew J Holmes
Funding Agency and Grant Number
Corresponding Author	Andrew J Holmes, PhD, School of Molecular Bioscience and Charles Perkins Centre, The University of Sydney, Building D17, Johns Hopkins Drive, Camperdown, NSW 2006, Australia. andrew.holmes@sydney.edu.au
Key Words	Microbiome; Dysbiosis; High fat diet; Bile; Intestinal mucosa; Microbe-associated molecular patterns; Short chain fatty acids; Immunomodulation; Enteroendocrine cells
Core Tip	The development of dysbiosis is driven by multiple factors. These include selective pressures imposed on the microbial community by the diet composition and feedback effects that involve either diet-host interaction or diet-microbiome-host interaction. The role of microbial signals in dysbiosis is well established but the involvement of host feedback mechanisms in aberrant host-microbial interactions is an under-appreciated part of disease progression. New opportunities to intervene in diseases of dysbiosis can result from targeting these distinct processes. These include stimulation of the host ability to self-regulate and blocking of deleterious host responses.
Publish Date	2014-12-02 10:46
Citation	Ha CWY, Lam YY, Holmes AJ. Mechanistic links between gut microbial community dynamics, microbial functions and metabolic health. World J Gastroenterol 2014; 20(44): 16498-16517
URL	http://www.wjgnet.com/1007-9327/full/v20/i44/16498.htm
DOI	http://dx.doi.org/10.3748/wjg.v20.i44.16498

Full Article (PDF)	WJG-20-16498.pdf
Full Article (Word)	WJG-20-16498.doc
Manuscript File	10417-Review.docx
Answering Reviewers	10417-Answering reviewers.pdf
Copyright License Agreement	10417-Copyright assignment.pdf
Peer-review Report	10417-Peer review(s).pdf
Scientific Misconduct Check	10417-CrossCheck.jpg
Scientific Editor Work List	10417-Scientific editor work list.pdf