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3/13/2025 10:11:00 AM | Browse: 24 | Download: 35
Publication Name World Journal of Gastroenterology
Manuscript ID 104170
Country United Kingdom
Received
2024-12-12 07:27
Peer-Review Started
2024-12-12 07:28
To Make the First Decision
Return for Revision
2025-01-15 19:51
Revised
2025-01-28 23:15
Second Decision
2025-02-14 02:36
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief
2025-02-14 05:10
Articles in Press
2025-02-14 05:10
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript
2025-02-27 06:11
Publish the Manuscript Online
2025-03-13 10:11
ISSN 1007-9327 (print) and 2219-2840 (online)
Open Access This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Copyright © The Author(s) 2024. Published by Baishideng Publishing Group Inc. All rights reserved.
Article Reprints For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Category Oncology
Manuscript Type Review
Article Title Cholangiocarcinoma: The era of liquid biopsy
Manuscript Source Invited Manuscript
All Author List Evgenia Kotsifa, Francesca Saffioti and Vasileios K Mavroeidis
ORCID
Author(s) ORCID Number
Evgenia Kotsifa http://orcid.org/0000-0002-0788-7009
Francesca Saffioti http://orcid.org/0000-0001-7635-9931
Vasileios K Mavroeidis http://orcid.org/0000-0002-8188-3575
Funding Agency and Grant Number
Corresponding Author Vasileios K Mavroeidis, Chief Physician, MD, Department of Transplant Surgery, North Bristol NHS Trust, Southmead Hospital, Southmead Road, Bristol BS10 5NB, United Kingdom. vasileios.mavroeidis@nhs.net
Key Words Biliary tract cancer; Circulating tumour cells; Cell free DNA; Circulating tumour DNA; Circulating RNA; Biomarkers; Extracellular vesicles; Precision medicine
Core Tip Cholangiocarcinoma (CCA) is an aggressive and heterogeneous malignancy that presents significant challenges in early detection, prognostication and monitoring using current diagnostic methods. Liquid biopsy (LB) emerges as a promising non-invasive technique, leveraging circulating tumour cells, cell-free DNA, circulating tumour DNA, RNA and extracellular vesicles as biomarkers. This review highlights the potential of LB to transform CCA management by improving early diagnosis, providing better prognostic insights and enabling dynamic patient monitoring. While LB shows substantial promise, critical limitations remain, necessitating further research to validate and optimise its integration into precision oncology for CCA.
Publish Date 2025-03-13 10:11
Citation <p>Kotsifa E, Saffioti F, Mavroeidis VK. Cholangiocarcinoma: The era of liquid biopsy. <i>World J Gastroenterol</i> 2025; 31(11): 104170</p>
URL https://www.wjgnet.com/1007-9327/full/v31/i11/104170.htm
DOI https://dx.doi.org/10.3748/wjg.v31.i11.104170
Full Article (PDF) WJG-31-104170-with-cover.pdf
Manuscript File 104170_Auto_Edited_012220.docx
Answering Reviewers 104170-answering-reviewers.pdf
Audio Core Tip 104170-audio.m4a
Conflict-of-Interest Disclosure Form 104170-conflict-of-interest-statement.pdf
Copyright License Agreement 104170-copyright-assignment.pdf
Peer-review Report 104170-peer-reviews.pdf
Scientific Misconduct Check 104170-scientific-misconduct-check.png
Scientific Editor Work List 104170-scientific-editor-work-list.pdf
CrossCheck Report 104170-crosscheck-report.png
CrossCheck Report 104170-crosscheck-report.pdf