| ISSN |
2218-4333 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Cell Biology |
| Manuscript Type |
Basic Study |
| Article Title |
Candida albicans and colorectal cancer: A paradoxical role revealed through metabolite profiling and prognostic modeling
|
| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Hao-Ling Zhang, Rui Zhao, Di Wang, Siti Nurfatimah Mohd Sapudin, Badrul Hisham Yahaya, Mohammad Syamsul Reza Harun, Zhong-Wen Zhang, Zhi-Jing Song, Yan-Ting Liu, Sandai Doblin and Ping Lu |
| ORCID |
|
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| Gansu Province Joint Fund General Program |
24JRRA878 |
| Gansu Provincial Science and Technology Program Project |
24JRRA1020 |
| Gansu Province Key Talent Program |
2025RCXM006 |
| Teaching Research and Reform Program for Postgraduate Education at Gansu University of Traditional Chinese Medicine (GUSTCM) |
YBXM-202406 |
| Special Fund for Mentors of “Qihuang Talents” in the First-Level Discipline of Chinese Medicine |
ZYXKBD-202415 |
|
| Corresponding Author |
Sandai Doblin, Professor, Department of Biomedical Sciences, Advanced Medical and Dental Institute, Universiti Sains Malaysia, Kepala Batas, Penang 13200, Malaysia. doblin@usm.my |
| Key Words |
Candida albicans; Colorectal cancer; metabolic characteristics; extracellular ATP; Prognostic model |
| Core Tip |
This study explores the paradoxical role of Candida albicans (C. albicans) in colorectal cancer (CRC), focusing on its tumor-modulating effects through metabolic interactions. A novel prognostic model incorporating five mRNA markers—EHD4, LIME1, GADD45B, TIMP1, and FDFT1—was developed, providing a framework for CRC risk assessment. The C. albicans metabolite mixture demonstrated a significant inhibitory effect on CRC initiation by reducing cell viability, altering gene expression, impairing migratory and invasive abilities, and promoting apoptosis without affecting ROS accumulation. The study highlights the potential of C. albicans metabolites as a therapeutic avenue in CRC management. |
| Publish Date |
2025-03-26 10:16 |
| Citation |
<p>Zhang HL, Zhao R, Wang D, Mohd Sapudin SN, Yahaya BH, Harun MSR, Zhang ZW, Song ZJ, Liu YT, Doblin S, Lu P. Candida albicans and colorectal cancer: A paradoxical role revealed through metabolite profiling and prognostic modeling. <i>World J Clin Oncol</i> 2025; 16(4): 104182</p> |
| URL |
https://www.wjgnet.com/2218-4333/full/v16/i4/104182.htm |
| DOI |
https://dx.doi.org/10.5306/wjco.v16.i4.104182 |
