Publication Name	World Journal of Gastroenterology
Manuscript ID	10421
Country	Canada

Received	2014-03-31 09:31
Peer-Review Started	2014-03-31 17:52
To Make the First Decision	2014-05-29 19:07
Return for Revision	2014-06-04 11:12
Revised	2014-06-05 08:14
Second Decision	2014-07-22 16:54
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief	2014-07-22 18:17
Articles in Press	2014-07-22 18:32
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2014-11-27 14:14
Publish the Manuscript Online	2014-12-18 17:08

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access
Copyright
Article Reprints	For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions	For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher	Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website	http://www.wjgnet.com

Category	Oncology
Manuscript Type	Autobiography
Article Title	Pea3 expression promotes the invasive and metastatic potential of colorectal carcinoma
Manuscript Source	Unsolicited Manuscript
All Author List	Aruz Mesci, Samira Taeb, Xiaoyong Huang, Rishi Jairath, Darshan Sivaloganathan and Stanley K Liu
Funding Agency and Grant Number	Funding Agency Grant Number Early investigator award from the Ontario Institute for Cancer Research to Liu SK Canada Foundation for Innovation - MEDI ORF
Corresponding Author	Stanley K Liu, PhD, MD, Sunnybrook Health Sciences Centre, Sunnybrook Research Institute, 2075 Bayview Avenue, Rm T2-14, Toronto, Ontario M4N 3M5, Canada. stanley.liu@sunnybrook.ca
Key Words	Colorectal cancer; Pea3; Epithelial-mesenchymal transition; Liver metastasis
Core Tip	Colorectal carcinoma (CRC) is one of the leading causes of cancer mortality. Pea3 is a transcription factor that has been implicated in the pathogenesis of CRC. We demonstrate that Pea3 directly influences metastatic potential in CRC using a model of liver metastases. We provide supporting findings that CRC invasiveness, anoikis and matrix metalloproteinase activity are influenced by Pea3, and that this may collectively contribute to altered metastatic potential. Our research provides an important biological rationale to explain previously reported clinical findings that elevated Pea3 expression in human tumors is correlated with increased metastatic potential and decreased overall survival.
Publish Date	2014-12-18 17:08
Citation	Mesci A, Taeb S, Huang X, Jairath R, Sivaloganathan D, Liu SK. Pea3 expression promotes the invasive and metastatic potential of colorectal carcinoma. World J Gastroenterol 2014; 20(46): 17376-17387
URL	http://www.wjgnet.com/1007-9327/full/v20/i46/17376.htm
DOI	http://dx.doi.org/10.3748/wjg.v20.i46.17376

Full Article (PDF)	WJG-20-17376.pdf
Full Article (Word)	WJG-20-17376.doc
Manuscript File	10421-Review.doc
Answering Reviewers	10421-Answering reviewers.pdf
Copyright License Agreement	10421-Copyright assignment.pdf
Peer-review Report	10421-Peer review(s).pdf
Scientific Misconduct Check	10421-CrossCheck.jpg
Scientific Editor Work List	10421-Scientific editor work list.pdf