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Articles Published Processes
2/28/2025 10:47:00 AM | Browse: 30 | Download: 61
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Received |
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2024-12-17 08:09 |
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Peer-Review Started |
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2024-12-18 00:06 |
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2025-01-12 07:36 |
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2025-01-14 12:31 |
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2025-01-22 02:32 |
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Accepted by Journal Editor-in-Chief |
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Accepted by Executive Editor-in-Chief |
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2025-01-22 06:46 |
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Articles in Press |
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2025-01-22 06:46 |
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Publication Fee Transferred |
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Edit the Manuscript by Language Editor |
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2025-01-25 14:19 |
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Typeset the Manuscript |
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2025-02-15 06:42 |
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Publish the Manuscript Online |
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2025-02-28 10:47 |
| ISSN |
1948-9358 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Letter to the Editor |
| Article Title |
Plantamajoside mitigates endoplasmic reticulum stress-mediated pancreatic β-cell apoptosis in type 2 diabetes via DNAJC1 upregulation
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| Manuscript Source |
Invited Manuscript |
| All Author List |
Md Abdul Alim Al-Bari, Fabian Davamani, Payal Bhatnagar and Nabil Eid |
| ORCID |
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| Funding Agency and Grant Number |
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| Corresponding Author |
Nabil Eid, Assistant Professor, Associate Professor, MD, PhD, Department of Anatomy, Division of Human Biology, School of Medicine, IMU University, Bukit Jalil, Kuala Lumpur 57000, Malaysia. nabilsaleheid@imu.edu.my |
| Key Words |
Plantamajoside; Type 2 diabetes mellitus; PI3K/AKT/NF-κB pathway; Endoplasmic stress; Metformin; DNAJC1; Apoptosis; Autophagy |
| Core Tip |
Type 2 diabetes mellitus (T2DM) is a chronic metabolic disorder with no known cure, representing significant challenges in both early diagnosis and treatment. Wang et al explored the effects of Plantamajoside (PMS) on pancreatic β-cell function using in vitro and in vivo animal models of T2DM. The authors determined the protective effect of PMS on MIN6 insulinoma cells and diabetic mice via upregulation of DNAJC1, suppressing endoplasmic reticulum stress and apoptosis of pancreatic β-cells. This discovery suggests promising advances in the clinical management of T2DM patients; however, transforming these results into clinical interventions demands further mechanistic elucidation and verification. |
| Publish Date |
2025-02-28 10:47 |
| Citation |
<p>Al-Bari MAA, Davamani F, Bhatnagar P, Eid N. Plantamajoside mitigates endoplasmic reticulum stress-mediated pancreatic β-cell apoptosis in type 2 diabetes via DNAJC1 upregulation. <i>World J Diabetes</i> 2025; 16(4): 104241</p> |
| URL |
https://www.wjgnet.com/1948-9358/full/v16/i4/104241.htm |
| DOI |
https://dx.doi.org/10.4239/wjd.v16.i4.104241 |
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