Publication Name	World Journal of Clinical Cases
Manuscript ID	104255
Country	China

Received	2024-12-23 12:15
Peer-Review Started	2024-12-23 12:15
To Make the First Decision
Return for Revision	2025-03-12 06:49
Revised	2025-03-24 03:43
Second Decision	2025-05-09 02:50
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2025-05-10 00:59
Articles in Press	2025-05-10 00:59
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2025-05-30 13:01
Publish the Manuscript Online	2025-06-16 06:25

ISSN	2307-8960 (online)
Open Access	This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
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Category	Oncology
Manuscript Type	Letter to the Editor
Article Title	Mechanism of action of cuproptosis and prospects for anti-tumor therapy
Manuscript Source	Invited Manuscript
All Author List	Jie Xiao, Yan Wang and Xiao-Jun Yang
ORCID	Author(s) ORCID Number Xiao-Jun Yang http://orcid.org/0000-0003-3770-8451
Funding Agency and Grant Number
Corresponding Author	Xiao-Jun Yang, Associate Professor, Chief Physician, MD, The First Clinical Medical School of Lanzhou University, Lanzhou University, No.199, Donggang West Road, Chengguan District, Lanzhou City, Gansu Province, China., Lanzhou 730000, Gansu Province, China. yangxjmd@aliyun.com
Key Words	Cuproptosis; Long non-coding RNAs; Colorectal cancer
Core Tip	This study reveals that copper ion-induced precipitation modifies mitochondrial proteins, promoting cell death. Low expression of the associated gene pyruvate dehydrogenase A1 is significantly correlated with improved overall survival in esophageal cancer patients. Tumor cells, characterized by disturbances in copper metabolism, display increased susceptibility to cuproptosis, eliciting diverse outcomes in distinct tumor types. Therefore, investigating the roles of cuproptosis-related genes and long non-coding RNAs in various tumors provides new directions for precision therapies targeting the cuproptosis pathway.
Publish Date	2025-06-16 06:25
Citation	<p>Xiao J, Wang Y, Yang XJ. Mechanism of action of cuproptosis and prospects for anti-tumor therapy. <i>World J Clin Cases</i> 2025; 13(24): 104255</p>
URL	https://www.wjgnet.com/2307-8960/full/v13/i24/104255.htm
DOI	https://dx.doi.org/10.12998/wjcc.v13.i24.104255

Full Article (PDF)	WJCC-13-104255-with-cover.pdf
Manuscript File	104255_Auto_Edited_062100.docx
Answering Reviewers	104255-answering-reviewers.pdf
Audio Core Tip	104255-audio.mp3
Conflict-of-Interest Disclosure Form	104255-conflict-of-interest-statement.pdf
Copyright License Agreement	104255-copyright-assignment.pdf
Non-Native Speakers of English Editing Certificate	104255-non-native-speakers.pdf
Peer-review Report	104255-peer-reviews.pdf
Scientific Misconduct Check	104255-scientific-misconduct-check.png
Scientific Editor Work List	104255-scientific-editor-work-list.pdf
CrossCheck Report	104255-crosscheck-report.pdf