Publication Name	World Journal of Radiology
Manuscript ID	104272
Country	China

Received	2024-12-16 03:53
Peer-Review Started	2024-12-16 03:53
To Make the First Decision
Return for Revision	2025-03-05 04:29
Revised	2025-03-16 13:46
Second Decision	2025-04-10 03:10
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2025-04-11 02:19
Articles in Press	2025-04-11 02:19
Publication Fee Transferred	2025-03-18 15:47
Edit the Manuscript by Language Editor	2025-04-18 00:30
Typeset the Manuscript	2025-05-21 00:53
Publish the Manuscript Online	2025-05-26 07:26

ISSN	1949-8470 (online)
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Category	Gastroenterology & Hepatology
Manuscript Type	Observational Study
Article Title	Diagnostic accuracy of noninvasive steatosis biomarkers with magnetic resonance imaging proton density fat fraction as gold standard
Manuscript Source	Unsolicited Manuscript
All Author List	Jia-Liang Chen, Shao-Jie Duan, Sheng Xie and Shu-Kun Yao
ORCID	Author(s) ORCID Number Jia-Liang Chen http://orcid.org/0000-0002-3007-0451 Shu-Kun Yao http://orcid.org/0000-0002-4826-5169
Funding Agency and Grant Number	Funding Agency Grant Number the Leap-forward Development Program for Beijing Biopharmaceutical Industry (G20) Z171100001717008 the Fundamental Research Funds for the Central Universities and Research projects on biomedical transformation of China-Japan Friendship Hospital PYBZ1815
Corresponding Author	Shu-Kun Yao, Chief Physician, MD, Professor, Department of Gastroenterology, China-Japan Friendship Hospital, No. 2 Yinghua East Road, Chaoyang District, Beijing 100029, China., Beijing 100029, China. yao_sk@126.com
Key Words	Nonalcoholic fatty liver disease; Diagnosis; Noninvasive biomarker; Magnetic resonance imaging proton density fat fraction; Chinese population
Core Tip	This is the first study to investigate the accuracy of noninvasive biomarkers for detecting nonalcoholic fatty liver disease (NAFLD) based on magnetic resonance imaging proton density fat fraction (MRI-PDFF) in the Chinese population, which is currently considered a novel gold standard for hepatic steatosis. Two types of cut-offs (single optimal cut-off and dual cut-off) of six steatosis biomarkers were analyzed. These noninvasive steatosis biomarkers demonstrated great accuracy in diagnosing NAFLD (MRI-PDFF ≥ 5%) and exhibited a strong correlation with MRI-PDFF. However, they may be ineffective in the detection of moderate or severe steatosis.
Publish Date	2025-05-26 07:26
Citation	<p>Chen JL, Duan SJ, Xie S, Yao SK. Diagnostic accuracy of noninvasive steatosis biomarkers with magnetic resonance imaging proton density fat fraction as gold standard. <i>World J Radiol</i> 2025; 17(5): 104272</p>
URL	https://www.wjgnet.com/1949-8470/full/v17/i5/104272.htm
DOI	https://dx.doi.org/10.4329/wjr.v17.i5.104272

Full Article (PDF)	WJR-17-104272-with-cover.pdf
STROBE Statement	104272-STROBE-statement.pdf
Manuscript File	104272_Auto_Edited_074249.docx
Answering Reviewers	104272-answering-reviewers.pdf
Audio Core Tip	104272-audio.m4a
Biostatistics Review Certificate	104272-biostatistics-statement.pdf
Conflict-of-Interest Disclosure Form	104272-conflict-of-interest-statement.pdf
Copyright License Agreement	104272-copyright-assignment.pdf
Approved Grant Application Form(s) or Funding Agency Copy of any Approval Document(s)	104272-foundation-statement.pdf
Signed Informed Consent Form(s) or Document(s)	104272-informed-consent-statement.pdf
Institutional Review Board Approval Form or Document	104272-institutional-review-board-statement.pdf
Non-Native Speakers of English Editing Certificate	104272-non-native-speakers.pdf
Supplementary Material	104272-supplementary-material.pdf
Peer-review Report	104272-peer-reviews.pdf
Scientific Misconduct Check	104272-scientific-misconduct-check.png
Scientific Editor Work List	104272-scientific-editor-work-list.pdf
CrossCheck Report	104272-crosscheck-report.pdf