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Articles Published Processes
8/27/2025 3:44:01 AM | Browse: 52 | Download: 89
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Received |
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2024-12-16 03:57 |
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Peer-Review Started |
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2024-12-16 03:57 |
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To Make the First Decision |
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Return for Revision |
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2025-02-20 02:44 |
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Revised |
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2025-03-27 00:32 |
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Second Decision |
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2025-08-05 02:46 |
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Accepted by Journal Editor-in-Chief |
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Accepted by Executive Editor-in-Chief |
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2025-08-06 00:59 |
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Articles in Press |
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2025-08-06 00:59 |
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Publication Fee Transferred |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2025-08-15 00:38 |
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Publish the Manuscript Online |
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2025-08-27 03:44 |
| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2024. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Immunology |
| Manuscript Type |
Basic Study |
| Article Title |
Sex based relative expression of estrogen receptors and tumor necrosis factor-alpha in liver affects hepatitis C virus viral pathogenesis
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| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Sarah Groover, Sarah Addison, Savannah Nicks, Mitchelle Mwangi, Amy Brooks, Anil Kaul and Rashmi Kaul |
| ORCID |
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| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| Cancer Sucks, Bixby, Oklahoma Research Grant |
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| Corresponding Author |
Rashmi Kaul, PhD, Professor, Department of Biochemistry and Microbiology, Oklahoma State University Center for Health Sciences, 1111 W 17th St, Tulsa, OK 74017, United States. rashmi.kaul10@okstate.edu |
| Key Words |
Hepatocellular carcinoma; Hepatitis C virus; Inflammation; Estrogen receptor; Liver cirrhosis; Tumor necrosis factor alpha |
| Core Tip |
Our study, for the first time, demonstrates an increase in expression of estrogen receptor (ER) β compared to ERα in the liver of normal males and females. In addition, ERβ message RNA expression was found to be decreased in hepatitis C virus (HCV)/cirrhosis and HCV/hepatocellular carcinoma livers, while tumor necrosis factor-α expression was increased. Further analysis of the data revealed sex-specific correlations between ERα and ERβ. These findings suggest that changes in ERβ expression are associated with worsening HCV-related disease, and may be one of the sex-dependent factors in cirrhosis and hepatocellular carcinoma pathogenesis. |
| Publish Date |
2025-08-27 03:44 |
| Citation |
<p>Groover S, Addison S, Nicks S, Mwangi M, Brooks A, Kaul A, Kaul R. Sex based relative expression of estrogen receptors and tumor necrosis factor-alpha in liver affects hepatitis C virus viral pathogenesis. <i>World J Gastroenterol</i> 2025; 31(32): 104277</p> |
| URL |
https://www.wjgnet.com/1007-9327/full/v31/i32/104277.htm |
| DOI |
https://dx.doi.org/10.3748/wjg.v31.i32.104277 |
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