| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Medicine, General & Internal |
| Manuscript Type |
Basic Study |
| Article Title |
LncRNA FTX promotes colorectal cancer radioresistance through disturbing redox balance and inhibiting ferroptosis via miR-625-5p/SCL7A11 axis
|
| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Qing Dai, Tian-Yin Qu, Jin-Lan Yang, Jing Leng, Lin Fang, Qian-Qian Zhu, Ke-Bi Wu, Jie Wu, Jing-Jing Ma and Huang-Fei Yu |
| ORCID |
|
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| National Natural Science Foundation of China |
81960506 |
| Science and Technology Fund project of Guizhou Provincial Health Commission |
gzwkj2022-299 |
| Key Projects of Zunyi Science and Technology Fund |
zunshikeheHZzi(2023)24 |
| Key Projects of Zunyi Science and Technology Fund |
zunshikeheHZzi(2024)9 |
|
| Corresponding Author |
Huang-Fei Yu, MD, Department of Oncology, Cancer Disease Research Institute, The Third Affiliated Hospital of Zunyi Medical University (The First People’s Hospital of Zunyi), 98# Fenghuang Road, Zunyi, Guizhou Province, 563003, P. R. China, Zunyi 563000, Guizhou Province, China. huangfeiyu@zmu.edu.cn |
| Key Words |
Colorectal cancer; LncRNA FTX; Solute carrier family 7 member 11; Ferroptosis; Redox; Radioresistance |
| Core Tip |
Radiotherapy is widely employed in colorectal cancer (CRC) treatment, but the occurrence of radioresistance severely limits the clinical benefit to patients and significantly contributes to treatment failure and recurrent metastasis. In this study, our results demonstrated that inhibition of the lncRNA FTX/miR-625-5p/SLC7A11 axis can induce ferroptosis and disturb intracellular redox balance, further sensitizing CRC cells to ionizing radiation, suggesting its potential as a therapeutic target for improving CRC response to radiation therapy. |
| Publish Date |
2025-04-27 03:54 |
| Citation |
<p>Dai Q, Qu TY, Yang JL, Leng J, Fang L, Zhu QQ, Wu KB, Wu J, Ma JJ, Yu HF. LncRNA FTX promotes colorectal cancer radioresistance through disturbing redox balance and inhibiting ferroptosis via miR-625-5p/SCL7A11 axis. <i>World J Gastroenterol</i> 2025; 31(16): 104305</p> |
| URL |
https://www.wjgnet.com/1007-9327/full/v31/i16/104305.htm |
| DOI |
https://dx.doi.org/10.3748/wjg.v31.i16.104305 |
