Publication Name	World Journal of Gastrointestinal Oncology
Manuscript ID	104341
Country	Türkiye

Received	2024-12-18 08:40
Peer-Review Started	2024-12-18 08:40
To Make the First Decision
Return for Revision	2025-01-24 02:32
Revised	2025-02-02 20:18
Second Decision	2025-02-28 02:34
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2025-02-28 06:23
Articles in Press	2025-02-28 06:23
Publication Fee Transferred	2025-02-04 19:37
Edit the Manuscript by Language Editor
Typeset the Manuscript	2025-04-27 09:20
Publish the Manuscript Online	2025-05-15 10:28

ISSN	1948-5204 (online)
Open Access	This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/
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Category	Oncology
Manuscript Type	Retrospective Study
Article Title	Novel tumor marker index combining carcinoembryonic antigen and carbohydrate antigen 19-9: New prognostic factor for metastatic colorectal cancer
Manuscript Source	Unsolicited Manuscript
All Author List	Yusuf Ilhan, Onur Yazdan Balcik, Halil Goksel Guzel, Arif Hakan Onder, Bilgin Demir, Mehmet Nuri Baser, Ibrahim Karadag, Mehmet Fatih Ozbay, Tugrul Burak Genc, Sahnura Uzuntas, Oguz Poyrazoglu, Ismail Beypinar, Yakup Ergun and Banu Ozturk
ORCID	Author(s) ORCID Number Yusuf Ilhan http://orcid.org/0000-0002-2875-6876 Onur Yazdan Balcik http://orcid.org/0000-0002-3386-2075 Halil Goksel Guzel http://orcid.org/0000-0001-8310-1752 Arif Hakan Onder http://orcid.org/0000-0002-0121-5228 Bilgin Demir http://orcid.org/0000-0003-4380-9419 Mehmet Nuri Baser http://orcid.org/0000-0003-1809-5581 Ibrahim Karadag http://orcid.org/0000-0002-2356-6790 Mehmet Fatih Ozbay http://orcid.org/0000-0002-4239-8657 Tugrul Burak Genc http://orcid.org/0000-0002-1302-359X Sahnura Uzuntas http://orcid.org/0009-0003-8254-5417 Oguz Poyrazoglu http://orcid.org/0009-0008-0847-2869 Ismail Beypinar http://orcid.org/0000-0002-0853-4096 Yakup Ergun http://orcid.org/0000-0003-4784-6743 Banu Ozturk http://orcid.org/0000-0003-0290-8787
Funding Agency and Grant Number
Corresponding Author	Yusuf Ilhan, MD, Department of Medical Oncology, Antalya City Hospital, Gocerler, No. 5379 Street, Antalya 07080, Türkiye. dryusufilhan@gmail.com
Key Words	Colorectal cancer biomarkers; Metastatic colorectal cancer; Carcinoembryonic antigen; Carbohydrate antigen 19-9; Tumor marker index
Core Tip	The tumor marker index (TMI), derived from the combination of carcinoembryonic antigen and carbohydrate antigen 19-9, offers a novel and cost-effective approach to prognostication in metastatic colorectal cancer. This study demonstrates that a high TMI is independently associated with significantly shorter overall survival, with potential implications for risk stratification and individualized patient management. These findings highlight the clinical value of integrating TMI into routine practice for better outcome prediction.
Publish Date	2025-05-15 10:28
Citation	<p>Ilhan Y, Balcik OY, Guzel HG, Onder AH, Demir B, Baser MN, Karadag I, Ozbay MF, Genc TB, Uzuntas S, Poyrazoglu O, Beypinar I, Ergun Y, Ozturk B. Novel tumor marker index combining carcinoembryonic antigen and carbohydrate antigen 19-9: New prognostic factor for metastatic colorectal cancer. <i>World J Gastrointest Oncol</i> 2025; 17(5): 104341</p>
URL	https://www.wjgnet.com/1948-5204/full/v17/i5/104341.htm
DOI	https://dx.doi.org/10.4251/wjgo.v17.i5.104341

Full Article (PDF)	WJGO-17-104341-with-cover.pdf
Manuscript File	104341_Auto_Edited_073934.docx
Answering Reviewers	104341-answering-reviewers.pdf
Audio Core Tip	104341-audio.mp3
Biostatistics Review Certificate	104341-biostatistics-statement.pdf
Conflict-of-Interest Disclosure Form	104341-conflict-of-interest-statement.pdf
Copyright License Agreement	104341-copyright-assignment.pdf
Signed Informed Consent Form(s) or Document(s)	104341-informed-consent-statement.pdf
Institutional Review Board Approval Form or Document	104341-institutional-review-board-statement.pdf
Non-Native Speakers of English Editing Certificate	104341-non-native-speakers.pdf
Peer-review Report	104341-peer-reviews.pdf
Scientific Misconduct Check	104341-scientific-misconduct-check.png
Scientific Editor Work List	104341-scientific-editor-work-list.pdf
CrossCheck Report	104341-crosscheck-report.pdf