Publication Name	World Journal of Stem Cells
Manuscript ID	104367
Country	China

Received	2024-12-19 14:15
Peer-Review Started	2024-12-20 08:57
To Make the First Decision
Return for Revision	2025-03-11 08:16
Revised	2025-03-21 14:27
Second Decision	2025-04-30 02:45
Accepted by Journal Editor-in-Chief	2025-04-30 06:59
Accepted by Executive Editor-in-Chief	2025-05-13 07:30
Articles in Press	2025-05-13 07:30
Publication Fee Transferred	2025-03-24 09:24
Edit the Manuscript by Language Editor	2025-05-19 06:20
Typeset the Manuscript	2025-06-17 03:55
Publish the Manuscript Online	2025-06-25 10:17

ISSN	1948-0210 (online)
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Category	Cell Biology
Manuscript Type	Basic Study
Article Title	Reduced NRF2/Mfn2 activity promotes endoplasmic reticulum stress and senescence in adipose-derived mesenchymal stem cells in hypertrophic obese mice
Manuscript Source	Unsolicited Manuscript
All Author List	Jia Fang
ORCID	Author(s) ORCID Number Jia Fang http://orcid.org/0000-0001-8241-209X
Funding Agency and Grant Number	Funding Agency Grant Number National Natural Science Foundation of China 32000511 Medical Science and Technology Joint Construction Program of Henan Province LHGJ20230053
Corresponding Author	Jia Fang, Henan Key Laboratory of Stem Cell Clinical Application and Key Technology, Henan Provincial People’s Hospital, Zhengzhou University People’s Hospital, No. 7 Weiwu Road, Zhengzhou 450000, Henan Province, China. fangjiazd@zzu.edu.cn
Key Words	Adipose-derived mesenchymal stem cells; Senescence; Nuclear factor erythroid-derived 2, Endoplasmic reticulum stress; Mitofusin-2
Core Tip	We observed increased adipose-derived mesenchymal stem cell (ASC) senescence and endoplasmic reticulum (ER) stress, along with decreased nuclear factor erythroid-derived 2 (NRF2) activity, in a hypertrophic obese mouse model. Chromatin immunoprecipitation-quantitative polymerase chain reaction analysis revealed reduced NRF2 transcriptional activity against mitofusin-2 (Mfn2). The downregulation of NRF2 activity and MFN2 expression promoted senescence and ER stress in ASCs. Additionally, co-immunoprecipitation showed that MFN2 interacts with binding immunoglobulin protein. These findings suggest that NRF2 may regulate ER stress and senescence via MFN2 in ASCs of hypertrophic obese mice.
Publish Date	2025-06-25 10:17
Citation	<p>Fang J. Reduced NRF2/Mfn2 activity promotes endoplasmic reticulum stress and senescence in adipose-derived mesenchymal stem cells in hypertrophic obese mice. <i>World J Stem Cells</i> 2025; 17(6): 104367</p>
URL	https://www.wjgnet.com/1948-0210/full/v17/i6/104367.htm
DOI	https://dx.doi.org/10.4252/wjsc.v17.i6.104367

Full Article (PDF)	WJSC-17-104367-with-cover.pdf
The ARRIVE Guidelines	104367-The-ARRIVE-Guidelines.pdf
Manuscript File	104367_Auto_Edited_064334.docx
Answering Reviewers	104367-answering-reviewers.pdf
Audio Core Tip	104367-audio.m4a
Biostatistics Review Certificate	104367-biostatistics-statement.pdf
Conflict-of-Interest Disclosure Form	104367-conflict-of-interest-statement.pdf
Copyright License Agreement	104367-copyright-assignment.pdf
Approved Grant Application Form(s) or Funding Agency Copy of any Approval Document(s)	104367-foundation-statement.pdf
Institutional Animal Care and Use Committee Approval Form or Document	104367-institutional-animal-care-and-use-committee-statement.pdf
Non-Native Speakers of English Editing Certificate	104367-non-native-speakers.pdf
Supplementary Material	104367-supplementary-material.pdf
Peer-review Report	104367-peer-reviews.pdf
Journal Editor-in-Chief Review Report	104367-journal-editor-in-chief.pdf
Scientific Misconduct Check	104367-scientific-misconduct-check.png
Scientific Editor Work List	104367-scientific-editor-work-list.pdf
CrossCheck Report	104367-crosscheck-report.pdf