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6/25/2025 10:17:04 AM | Browse: 102 | Download: 566
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Received |
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2024-12-19 14:15 |
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Peer-Review Started |
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2024-12-20 08:57 |
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First Decision by Editorial Office Director |
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2025-03-11 08:16 |
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Return for Revision |
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2025-03-11 08:16 |
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Revised |
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2025-03-21 14:27 |
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Publication Fee Transferred |
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2025-03-24 09:24 |
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Second Decision by Editor |
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2025-04-30 02:45 |
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Second Decision by Editor-in-Chief |
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2025-04-30 06:59 |
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Final Decision by Editorial Office Director |
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2025-05-13 07:30 |
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Articles in Press |
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2025-05-13 07:30 |
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Edit the Manuscript by Language Editor |
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2025-05-19 06:20 |
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Typeset the Manuscript |
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2025-06-17 03:55 |
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Publish the Manuscript Online |
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2025-06-25 10:17 |
| ISSN |
1948-0210 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Cell Biology |
| Manuscript Type |
Basic Study |
| Article Title |
Reduced NRF2/Mfn2 activity promotes endoplasmic reticulum stress and senescence in adipose-derived mesenchymal stem cells in hypertrophic obese mice
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| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Jia Fang |
| ORCID |
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| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| National Natural Science Foundation of China |
32000511 |
| Medical Science and Technology Joint Construction Program of Henan Province |
LHGJ20230053 |
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| Corresponding Author |
Jia Fang, Henan Key Laboratory of Stem Cell Clinical Application and Key Technology, Henan Provincial People’s Hospital, Zhengzhou University People’s Hospital, No. 7 Weiwu Road, Zhengzhou 450000, Henan Province, China. fangjiazd@zzu.edu.cn |
| Key Words |
Adipose-derived mesenchymal stem cells; Senescence; Nuclear factor erythroid-derived 2, Endoplasmic reticulum stress; Mitofusin-2 |
| Core Tip |
We observed increased adipose-derived mesenchymal stem cell (ASC) senescence and endoplasmic reticulum (ER) stress, along with decreased nuclear factor erythroid-derived 2 (NRF2) activity, in a hypertrophic obese mouse model. Chromatin immunoprecipitation-quantitative polymerase chain reaction analysis revealed reduced NRF2 transcriptional activity against mitofusin-2 (Mfn2). The downregulation of NRF2 activity and MFN2 expression promoted senescence and ER stress in ASCs. Additionally, co-immunoprecipitation showed that MFN2 interacts with binding immunoglobulin protein. These findings suggest that NRF2 may regulate ER stress and senescence via MFN2 in ASCs of hypertrophic obese mice. |
| Publish Date |
2025-06-25 10:17 |
| Citation |
Fang J. Reduced NRF2/Mfn2 activity promotes endoplasmic reticulum stress and senescence in adipose-derived mesenchymal stem cells in hypertrophic obese mice. World J Stem Cells 2025; 17(6): 104367 |
| URL |
https://www.wjgnet.com/1948-0210/full/v17/i6/104367.htm |
| DOI |
https://dx.doi.org/10.4252/wjsc.v17.i6.104367 |
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