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Articles Published Processes
7/14/2025 12:55:53 PM | Browse: 21 | Download: 183
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Received |
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2024-12-20 10:33 |
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Peer-Review Started |
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2024-12-20 10:34 |
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First Decision by Editorial Office Director |
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2025-03-24 10:12 |
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Return for Revision |
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2025-03-24 10:12 |
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Revised |
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2025-04-08 04:10 |
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Publication Fee Transferred |
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2025-04-30 02:12 |
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Second Decision by Editor |
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2025-05-29 02:50 |
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Second Decision by Editor-in-Chief |
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Final Decision by Editorial Office Director |
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2025-05-29 07:48 |
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Articles in Press |
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2025-05-29 07:48 |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2025-06-27 07:13 |
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Publish the Manuscript Online |
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2025-07-14 12:55 |
| ISSN |
1948-5204 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Oncology |
| Manuscript Type |
Basic Study |
| Article Title |
Flap endonuclease-1 promotes pancreatic cancer progression via AKT/mTOR signaling pathway
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| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Yu Xia, Na Guo, Cheng-Lou Zhu, Jie-Yun Gao and Ming-Xu Da |
| ORCID |
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| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| Youth Science and Technology Fund Program of the Natural Science Foundation of Gansu Province |
21JR7RA645 and 23JRRA1317 |
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| Corresponding Author |
Ming-Xu Da, Department of Surgical Oncology, Gansu Provincial Hospital, No. 222 Tianshui South, Chengguan District, Lanzhou 730000, Gansu Province, China. ldyy_damx@lzu.edu.cn |
| Key Words |
Flap endonuclease-1; Pancreatic cancer; AKT/mTOR signaling pathway; Proliferation; Migration; Invasion |
| Core Tip |
This study elucidates the oncogenic role of flap endonuclease-1 (FEN1) in pancreatic cancer (PC), demonstrating its ability to promote cancer cell proliferation, migration, and invasion through modulation of the AKT/mTOR signaling pathway. Elevated FEN1 expression is closely associated with poor prognosis in PC patients, and FEN1 significantly enhances tumor growth both in vitro and in vivo. RNA sequencing, transcriptome analysis, and functional experiments further validate that the oncogenic effects of FEN1 are partially mediated by the activation of the AKT/mTOR signaling pathway, providing compelling evidence for FEN1 as a potential therapeutic target in PC. |
| Publish Date |
2025-07-14 12:55 |
| Citation |
Xia Y, Guo N, Zhu CL, Gao JY, Da MX. Flap endonuclease-1 promotes pancreatic cancer progression via AKT/mTOR signaling pathway. World J Gastrointest Oncol 2025; 17(7): 104402 |
| URL |
https://www.wjgnet.com/1948-5204/full/v17/i7/104402.htm |
| DOI |
https://dx.doi.org/10.4251/wjgo.v17.i7.104402 |
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