Publication Name	World Journal of Clinical Oncology
Manuscript ID	104413
Country	China

Received	2024-12-20 03:25
Peer-Review Started	2024-12-20 03:26
To Make the First Decision
Return for Revision	2025-01-10 09:46
Revised	2025-01-15 10:03
Second Decision	2025-02-25 02:50
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2025-02-25 10:32
Articles in Press	2025-02-25 10:32
Publication Fee Transferred	2025-01-17 14:37
Edit the Manuscript by Language Editor
Typeset the Manuscript	2025-03-14 01:44
Publish the Manuscript Online	2025-03-26 10:16

ISSN	2218-4333 (online)
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Category	Oncology
Manuscript Type	Case Report
Article Title	Diagnosis and treatment of pulmonary lymphoepithelioma-like carcinoma: A case report
Manuscript Source	Unsolicited Manuscript
All Author List	Feng-Ling Huang, Min Luo, Zhen-Mei He, Yong-Qi Shen and Guan-Da Liu
ORCID	Author(s) ORCID Number Feng-Ling Huang http://orcid.org/0009-0006-3337-3649 Guan-Da Liu http://orcid.org/0009-0006-5278-3088
Funding Agency and Grant Number	Funding Agency Grant Number Chinese Medicine Administration Bureau of Guangxi Zhuang Autonomous Region GXZYB20220472
Corresponding Author	Guan-Da Liu, MD, Department of Pharmacology and Clinical Pharmacy, Ruikang Hospital Affiliated to Guangxi University of Chinese Medicine, No. 10 Huadong Road, Nanning 530000, Guangxi Zhuang Autonomous Region, China. rkjp2024@163.com
Key Words	Pulmonary lymphoepithelioma-like carcinoma; Epstein-Barr virus; Anlotinib; Toripalimab; Case report
Core Tip	We report a case of a 38-year-old man who was diagnosed with right pulmonary lymphoepithelioma-like carcinoma (PLELC). Chest computed tomography (CT) revealed a mass in the medial segment of the middle lobe of the right lung, with lymph node metastasis in the mediastinum and right hilum of the lung. CT-guided lung tumor biopsy was performed and the postoperative pathological examination combined with immune phenotype analysis and in situ hybridization confirmed PLELC. Standard molecular testing for patients with non-small cell lung cancer was negative and programmed cell death ligand-1 expression was about 2%. However, the patient declined radiotherapy and chemotherapy treatment. Consequently, immunotherapy was administered, which included toripalimab 240 mg on day 1 and anlotinib 10 mg on days 1-14 for 10 cycles, followed by a maintenance dose of anlotinib 10 mg daily every 3 weeks. As a result, his progression-free survival reached 48 months. PLELC is a rare primary epithelial lung cancer. Currently, there is no standard treatment for PLELC. A combination of toripalimab and anlotinib may benefit patients with advanced diseases who have not received systematic anti-tumor therapy. However, its long-term efficacy requires further comprehensive research and validation.
Publish Date	2025-03-26 10:16
Citation	<p>Huang FL, Luo M, He ZM, Shen YQ, Liu GD. Diagnosis and treatment of pulmonary lymphoepithelioma-like carcinoma: A case report. <i>World J Clin Oncol</i> 2025; 16(4): 104413</p>
URL	https://www.wjgnet.com/2218-4333/full/v16/i4/104413.htm
DOI	https://dx.doi.org/10.5306/wjco.v16.i4.104413

Full Article (PDF)	WJCO-16-104413-with-cover.pdf
CARE Checklist–2016	104413-CARE-Checklist-2016.pdf
Manuscript File	104413_Auto_Edited_080307.docx
Answering Reviewers	104413-answering-reviewers.pdf
Audio Core Tip	104413-audio.mp3
Conflict-of-Interest Disclosure Form	104413-conflict-of-interest-statement.pdf
Copyright License Agreement	104413-copyright-assignment.pdf
Approved Grant Application Form(s) or Funding Agency Copy of any Approval Document(s)	104413-foundation-statement.pdf
Signed Consent for Treatment Form(s) or Document(s)	104413-informed-consent-statement.pdf
Non-Native Speakers of English Editing Certificate	104413-non-native-speakers.pdf
Peer-review Report	104413-peer-reviews.pdf
Scientific Misconduct Check	104413-scientific-misconduct-check.png
Scientific Editor Work List	104413-scientific-editor-work-list.pdf
CrossCheck Report	104413-crosscheck-report.pdf