Publication Name	World Journal of Gastroenterology
Manuscript ID	10445
Country	China

Received	2014-04-01 10:19
Peer-Review Started	2014-04-02 08:57
To Make the First Decision	2014-05-13 20:13
Return for Revision	2014-05-21 08:29
Revised	2014-06-08 00:00
Second Decision	2014-07-11 17:06
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2014-07-11 17:10
Articles in Press	2014-07-11 17:30
Publication Fee Transferred
Edit the Manuscript by Language Editor	2014-07-17 15:48
Typeset the Manuscript	2014-09-23 14:49
Publish the Manuscript Online	2014-10-16 15:53

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access
Copyright
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Publisher	Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website	http://www.wjgnet.com

Category	Gastroenterology & Hepatology
Manuscript Type	Retrospective Study
Article Title	Characteristics and clinical outcome of nonsteroidal anti-inflammatory drug-induced acute hepato-nephrotoxicity among Chinese patients
Manuscript Source	Unsolicited Manuscript
All Author List	Ya-Li Cao, Zhi-Gang Tian, Fang Wang, Wen-Ge Li, Dan-Ying Cheng, Yan-Fang Yang and Hong-Mei Gao
Funding Agency and Grant Number	Funding Agency Grant Number National Natural Science Foundation of China 81200535 China-Japan Friendship Hospital Youth Science and Technology Excellence Project 2014-QNYC-A-01
Corresponding Author	Wen-Ge Li, MD, PhD, Department of Nephrology, China-Japan Friendship Hospital, No. 2 Yinghua Street, Chaoyang District, Beijing 100029, China. yalicao050501@hotmail.com
Key Words	Nonsteroidal anti-inflammatory drug; Hepato-nephrotoxicity; Acute interstitial nephritis; Acute hepatitis; Cholestasis
Core Tip	This is the largest series to date demonstrating that nonsteroidal anti-inflammatory drugs are a common cause of acute combined hepato-nephrotoxicity in the Chinese population. The risk factors include age older than 60 years, alcohol use, positive hepatitis B virus markers, extracellular volume depletion and renin-angiotensin-aldosterone system inhibitor combined use. Acute tubulointerstitial disease and acute hepatitis were the major histological findings. Treatment for the patients comprised discontinuation of the implicated drugs and pulse methylprednisolone followed by oral steroids in some patients. Cyclophosphamide was added according to the histology. The prognosis was good with prompt diagnosis and treatment.
Publish Date	2014-10-16 15:53
Citation	Cao YL, Tian ZG, Wang F, Li WG, Cheng DY, Yang YF, Gao HM. Characteristics and clinical outcome of nonsteroidal anti-inflammatory drug-induced acute hepato-nephrotoxicity among Chinese patients. World J Gastroenterol 2014; 20(38): 13956-13965
URL	http://www.wjgnet.com/1007-9327/full/v20/i38/13956.htm
DOI	http://dx.doi.org/10.3748/wjg.v20.i38.13956

Full Article (PDF)	WJG-20-13956.pdf
Full Article (Word)	WJG-20-13956.doc
Manuscript File	10445-Review.doc
Answering Reviewers	10445-Answering reviewers.pdf
Copyright License Agreement	10445-Copyright assignment.pdf
Peer-review Report	10445-Peer review.pdf
Scientific Misconduct Check	10445-CrossCheck.jpg
Scientific Editor Work List	10445-Scientific editor work list.pdf