Publication Name	World Journal of Diabetes
Manuscript ID	104482
Country	China

Received	2024-12-24 05:41
Peer-Review Started	2024-12-24 09:21
To Make the First Decision
Return for Revision	2025-01-15 10:23
Revised	2025-02-05 15:38
Second Decision	2025-02-19 12:54
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2025-02-26 07:56
Articles in Press	2025-02-26 07:56
Publication Fee Transferred	2025-02-10 09:32
Edit the Manuscript by Language Editor
Typeset the Manuscript	2025-03-10 00:50
Publish the Manuscript Online	2025-04-25 07:53

ISSN	1948-9358 (online)
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Category	Endocrinology & Metabolism
Manuscript Type	Retrospective Cohort Study
Article Title	Systemic immune indicators for predicting renal damage in newly diagnosed type 1 diabetic children
Manuscript Source	Unsolicited Manuscript
All Author List	Lan-Fang Cao, Qing-Bo Xu and Li Yang
ORCID	Author(s) ORCID Number Li Yang http://orcid.org/0009-0003-5209-4766
Funding Agency and Grant Number	Funding Agency Grant Number Jiangxi Provincial Health Commission Science and Technology Plan SKJP220212334
Corresponding Author	Li Yang, Chief Physician, Professor, Department of Endocrinology, Jiangxi Provincial Children’s Hospital/The Affiliated Children’s Hospital of Nanchang Medical College, No. 1666 Diezihu Avenue, Honggutan District, Nanchang 330038, Jiangxi Province, China. yangli1@ncmc.edu.cn
Key Words	Pediatric type 1 diabetes mellitus; Systemic immune inflammation index; Kidney injury; Urinary albumin-to-creatinine ratio; Inflammatory markers
Core Tip	This study highlights the predictive value of systemic inflammatory markers - systemic immune inflammation index (SII), neutrophil-to-lymphocyte ratio, and platelet-to-lymphocyte ratio - for early kidney damage in children with newly diagnosed type 1 diabetes mellitus. SII emerged as a significant independent predictor of renal injury, with a high specificity threshold. The combination of SII with neutrophil-to-lymphocyte ratio or platelet-to-lymphocyte ratio further enhanced diagnostic accuracy. These simple, cost-effective markers provide valuable tools for early detection and intervention, paving the way for improved clinical strategies to prevent diabetic nephropathy in pediatric type 1 diabetes mellitus patients.
Publish Date	2025-04-25 07:53
Citation	<p>Cao LF, Xu QB, Yang L. Systemic immune indicators for predicting renal damage in newly diagnosed type 1 diabetic children. <i>World J Diabetes</i> 2025; 16(5): 104482</p>
URL	https://www.wjgnet.com/1948-9358/full/v16/i5/104482.htm
DOI	https://dx.doi.org/10.4239/wjd.v16.i5.104482

Full Article (PDF)	WJD-16-104482-with-cover.pdf
STROBE Statement	104482-STROBE-statement.pdf
Manuscript File	104482_Auto_Edited_081045.docx
Answering Reviewers	104482-answering-reviewers.pdf
Audio Core Tip	104482-audio.mp3
Biostatistics Review Certificate	104482-biostatistics-statement.pdf
Conflict-of-Interest Disclosure Form	104482-conflict-of-interest-statement.pdf
Copyright License Agreement	104482-copyright-assignment.pdf
Approved Grant Application Form(s) or Funding Agency Copy of any Approval Document(s)	104482-foundation-statement.pdf
Signed Informed Consent Form(s) or Document(s)	104482-informed-consent-statement.pdf
Institutional Review Board Approval Form or Document	104482-institutional-review-board-statement.pdf
Non-Native Speakers of English Editing Certificate	104482-non-native-speakers.pdf
Supplementary Material	104482-supplementary-material.pdf
Peer-review Report	104482-peer-reviews.pdf
Scientific Misconduct Check	104482-scientific-misconduct-check.png
Scientific Editor Work List	104482-scientific-editor-work-list.pdf
CrossCheck Report	104482-crosscheck-report.pdf