| ISSN |
2218-5836 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Medicine, Research & Experimental |
| Manuscript Type |
Systematic Reviews |
| Article Title |
Pathophysiology and management of Crush syndrome: A narrative review
|
| Manuscript Source |
Invited Manuscript |
| All Author List |
Shahnawaz Khan, Deepak Neradi, Nikhil Unnava, Mantu Jain and Sujit Kumar Tripathy |
| ORCID |
|
| Funding Agency and Grant Number |
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| Corresponding Author |
Sujit Kumar Tripathy, Department of Orthopaedics, All India Institute of Medical Sciences, SIjua, Patrapada, Bhubaneswar 751019, Odisha, India. sujitortho@yahoo.co.in |
| Key Words |
Muscle; Myoglobin; Acute kidney injury; Musculoskeletal injury; Fracture; Rhanbdomyolysis |
| Core Tip |
Crush syndrome is a life-threatening condition caused by traumatic rhabdomyolysis, resulting in systemic complications, particularly acute kidney injury (AKI). Pathophysiologically, muscle damage releases toxins such as myoglobin, potassium, and lactic acid into the bloodstream, leading to renal tubule damage, hyperkalemia-induced cardiac arrhythmias, metabolic acidosis, and coagulopathy. Modern insights highlight the role of ferroptosis, oxidative stress, and macrophage activity in AKI progression. Management emphasizes early recognition, fluid resuscitation, renal protection, and innovative therapies like antioxidants, hyperbaric oxygen, and erythropoietin. Comprehensive treatment also includes pre-hospital care, electrolyte correction, renal replacement therapy, and long-term rehabilitation to improve outcomes and quality of life. |
| Publish Date |
2025-04-17 08:25 |
| Citation |
Khan S, Neradi D, Unnava N, Jain M, Tripathy SK. Pathophysiology and management of Crush syndrome: A narrative review. World J Orthop 2025; 16(4): 104489 |
| URL |
https://www.wjgnet.com/2218-5836/full/v16/i4/104489.htm |
| DOI |
https://dx.doi.org/10.5312/wjo.v16.i4.104489 |
