| ISSN |
1948-9358 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
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| Permissions |
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Pharmacology & Pharmacy |
| Manuscript Type |
Basic Study |
| Article Title |
Examining gut microbiota and metabolites to clarify mechanisms of Dimocarpus longan Lour leaf components against type 2 diabetes
|
| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Piao-Xue Zheng, Chun-Lian Lu, Yan-Li Liang, Yu-Ming Ma, Jia-Wen Peng, Jing-Jing Xie, Jia-Li Wei, Si-Si Chen, Zhi-Dong Ma, Hua Zhu and Jie Liang |
| ORCID |
|
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| the National Natural Science Foundation of China |
82160771 |
| NATCM's Project of High-Level Construction of Key TCM Disciplines: Traditional Medicine of Chinese Minority (Zhuang Medicine) |
zyyzdxk-2023165 |
| Guangxi One Thousand Young and Middle-Aged College and University Backbones Teachers Cultivation Program |
[2019]5 |
| Guangxi Traditional Chinese Medicine Multidisciplinary Cross Innovation Team Project |
GZKJ2309 |
| Guangxi Key R&D Plan Project |
AB21196016 |
| Guangxi Key Discipline of Traditional Chinese Medicine Zhuang Pharmacy |
GZXK-Z-20-64 |
| The First-Class Subject of Traditional Chinese Medicine (Ethnic Pharmacy) in Guangxi |
[2018]12 |
| Guangxi Science and Technology Base and Talent Special Project |
AD20238058 and AD21238031 |
| Third Batch of Cultivating High-level Talent Teams in the “Qi Huang Project” of the Guangxi University of Chinese Medicine |
202406 |
| Huang Danian Style Teacher Team From Universities in Guangxi Zhuang Autonomous Region “Traditional Chinese Medicine Inheritance and Innovation Teacher Team” |
[2023]31 |
|
| Corresponding Author |
Jie Liang, PhD, Professor, College of Pharmacy, Guangxi University of Chinese Medicine, No. 13 Wuhe Avenue, Qingxiu District, Nanning 530200, Guangxi Zhuang Autonomous Region, China. liangj2004@gxtcmu.edu.cn |
| Key Words |
Dimocarpus longan Lour leaf components; Type 2 diabetes; 16S rDNA sequencing; Short-chain fatty acids; Metabolomics |
| Core Tip |
This study investigated the anti-type 2 diabetes mechanism of Dimocarpus longan Lour leaf components (DLC). Results showed that DLC modulated intestinal flora, short-chain fatty acids, and fecal metabolites. It might exert hypoglycemic effects via the gut microbiota-metabolite-host axis, offering new insights for diabetes treatment. |
| Publish Date |
2025-07-15 08:26 |
| Citation |
Zheng PX, Lu CL, Liang YL, Ma YM, Peng JW, Xie JJ, Wei JL, Chen SS, Ma ZD, Zhu H, Liang J. Examining gut microbiota and metabolites to clarify mechanisms of Dimocarpus longan Lour leaf components against type 2 diabetes. World J Diabetes 2025; 16(7): 104512 |
| URL |
https://www.wjgnet.com/1948-9358/full/v16/i7/104512.htm |
| DOI |
https://dx.doi.org/10.4239/wjd.v16.i7.104512 |
