Publication Name	World Journal of Hepatology
Manuscript ID	104520
Country	China

Received	2024-12-24 06:49
Peer-Review Started	2024-12-25 01:50
To Make the First Decision
Return for Revision	2025-02-14 08:51
Revised	2025-02-24 08:18
Second Decision	2025-03-06 02:38
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2025-03-06 10:24
Articles in Press	2025-03-06 10:24
Publication Fee Transferred	2025-02-25 09:39
Edit the Manuscript by Language Editor
Typeset the Manuscript	2025-03-18 09:31
Publish the Manuscript Online	2025-03-26 04:06

ISSN	1948-5182 (online)
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Category	Gastroenterology & Hepatology
Manuscript Type	Basic Study
Article Title	Mogroside V protects against acetaminophen-induced liver injury by reducing reactive oxygen species and c-jun-N-terminal kinase activation in mice
Manuscript Source	Unsolicited Manuscript
All Author List	Jia-Lin Shi, Tian Sun, Qing Li, Chun-Mei Li, Jun-Fei Jin and Chong Zhang
ORCID	Author(s) ORCID Number Jia-Lin Shi http://orcid.org/0009-0004-8794-1424 Qing Li http://orcid.org/0000-0003-3357-3254 Chun-Mei Li http://orcid.org/0000-0002-4962-7133 Jun-Fei Jin http://orcid.org/0000-0002-9918-0966 Chong Zhang http://orcid.org/0000-0002-6283-484X
Funding Agency and Grant Number	Funding Agency Grant Number Guangxi Natural Science Foundation of China 2024GXNSFAA010040 the Special Fund of the Central Government Guiding Local Scientific and Technological Development by Guangxi Science and Technology Department GuikeZY21195024 National Natural Science Foundation of China 82260499 and 82460463
Corresponding Author	Chong Zhang, Associate Professor, Guangxi Key Laboratory of Molecular Medicine in Liver Injury and Repair, the Affiliated Hospital of Guilin Medical University, 15 Lequn Road, Guilin 541001, Guangxi Zhuang Autonomous Region, China. chongzhang.1003@glmc.edu.cn
Key Words	Acetaminophen; Mogroside V; Reactive oxygen species; Liver injury; C-jun-N-terminal kinase
Core Tip	This study examines whether mogroside V (MV), a plant-derived triterpenoid, can mitigate acetaminophen (APAP)-induced acute liver injury (ALI). Both animal and cell experiments demonstrate that MV alleviates APAP-induced ALI by suppressing reactive oxygen species/c-jun-N-terminal kinase signaling independent of glutathione modulation. Our findings suggest that MV could serve as a potential prophylactic agent to prevent APAP-induced ALI.
Publish Date	2025-03-26 04:06
Citation	<p>Shi JL, Sun T, Li Q, Li CM, Jin JF, Zhang C. Mogroside V protects against acetaminophen-induced liver injury by reducing reactive oxygen species and c-jun-N-terminal kinase activation in mice. <i>World J Hepatol</i> 2025; 17(3): 104520</p>
URL	https://www.wjgnet.com/1948-5182/full/v17/i3/104520.htm
DOI	https://dx.doi.org/10.4254/wjh.v17.i3.104520

Full Article (PDF)	WJH-17-104520-with-cover.pdf
The ARRIVE Guidelines	104520-The-ARRIVE-Guidelines.pdf
Manuscript File	104520_Auto_Edited_010224.docx
Answering Reviewers	104520-answering-reviewers.pdf
Audio Core Tip	104520-audio.mp3
Biostatistics Review Certificate	104520-biostatistics-statement.pdf
Conflict-of-Interest Disclosure Form	104520-conflict-of-interest-statement.pdf
Copyright License Agreement	104520-copyright-assignment.pdf
Approved Grant Application Form(s) or Funding Agency Copy of any Approval Document(s)	104520-foundation-statement.pdf
Institutional Animal Care and Use Committee Approval Form or Document	104520-institutional-animal-care-and-use-committee-statement.pdf
Institutional Review Board Approval Form or Document	104520-institutional-review-board-statement.pdf
Non-Native Speakers of English Editing Certificate	104520-non-native-speakers.pdf
Peer-review Report	104520-peer-reviews.pdf
Scientific Misconduct Check	104520-scientific-misconduct-check.png
Scientific Editor Work List	104520-scientific-editor-work-list.pdf
CrossCheck Report	104520-crosscheck-report.pdf