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Articles Published Processes
5/15/2025 10:29:03 AM | Browse: 53 | Download: 152
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Received |
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2024-12-27 15:00 |
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Peer-Review Started |
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2024-12-27 15:00 |
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To Make the First Decision |
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Return for Revision |
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2025-02-13 08:56 |
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Revised |
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2025-02-27 02:24 |
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Second Decision |
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2025-04-21 02:37 |
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Accepted by Journal Editor-in-Chief |
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Accepted by Executive Editor-in-Chief |
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2025-04-21 09:07 |
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Articles in Press |
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2025-04-21 09:07 |
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Publication Fee Transferred |
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2025-03-04 08:30 |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2025-04-27 23:35 |
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Publish the Manuscript Online |
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2025-05-15 10:29 |
| ISSN |
1948-5204 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2024. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Oncology |
| Manuscript Type |
Basic Study |
| Article Title |
Simvastatin inhibits proliferation and migration, promotes oxidative stress and ferroptosis in colon cancer
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| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Ying Liu, Hao Ge, Zhi-Min Fan, Ting Lu, Lei He, Meng Li, Hao-Ran Zhao and Qiang Leng |
| ORCID |
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| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| Jiangsu Province Key Research and Development Plan (Social Development) Project |
No. BE2021611 |
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| Corresponding Author |
Qiang Leng, Department of Colon and Rectal Surgery, Nanjing Hospital of Chinese Medicine Affiliated to Nanjing University of Chinese Medicine, No. 157 Daming Road, Qinhuai District, Nanjing 210022, Jiangsu Province, China. 18115470206@163.com |
| Key Words |
Simvastatin; Colon cancer; Ferroptosis; SERPINE1; Cyclic guanosine monophosphate-protein kinase G pathway |
| Core Tip |
Simvastatin significantly reduces the proliferation and migration of HCT-116 and SW620 colon cancer cell lines in a dose-dependent manner, while promoting apoptosis. Treatment with simvastatin enhances oxidative stress markers (reactive oxygen species, malondialdehyde, ferrous ion) and decreases glutathione levels, indicating its potential to induce ferroptosis in colon cancer cells through the modulation of the cyclic guanosine monophosphate-protein kinase G signaling pathway. SERPINE1 was identified as a core target of simvastatin, with its downregulation linked to increased GUCY1B1 and PRKG1 levels, suggesting a crucial role in the drug’s mechanism of action. |
| Publish Date |
2025-05-15 10:29 |
| Citation |
<p>Liu Y, Ge H, Fan ZM, Lu T, He L, Li M, Zhao HR, Leng Q. Simvastatin inhibits proliferation and migration, promotes oxidative stress and ferroptosis in colon cancer. <i>World J Gastrointest Oncol</i> 2025; 17(5): 104522</p> |
| URL |
https://www.wjgnet.com/1948-5204/full/v17/i5/104522.htm |
| DOI |
https://dx.doi.org/10.4251/wjgo.v17.i5.104522 |
© 2004-2025 Baishideng Publishing Group Inc. All rights reserved. 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
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