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Articles Published Processes
4/11/2025 2:19:31 AM | Browse: 66 | Download: 392
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Received |
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2024-12-24 06:38 |
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Peer-Review Started |
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2024-12-24 06:39 |
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First Decision by Editorial Office Director |
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2025-02-13 23:31 |
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Return for Revision |
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2025-02-13 23:31 |
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Revised |
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2025-02-25 09:32 |
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Publication Fee Transferred |
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Second Decision by Editor |
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2025-03-13 02:33 |
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Second Decision by Editor-in-Chief |
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Final Decision by Editorial Office Director |
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2025-03-13 03:18 |
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Articles in Press |
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2025-03-13 03:18 |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2025-04-03 06:51 |
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Publish the Manuscript Online |
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2025-04-11 02:19 |
| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2024. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Letter to the Editor |
| Article Title |
Mixed lineage kinase domain-like protein in liver diseases: Cell-type-specific functions and dual roles
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| Manuscript Source |
Invited Manuscript |
| All Author List |
Ming-Xing Liang, Ying Zhou, Su-Qun Li, Wan-Sheng Xiang, Zong-Qin Pan, Ying-Hua Chen and Yi-Huai He |
| ORCID |
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| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| Science and Technology Planning Projects of Guizhou Province |
No. QKHJC-ZK[2022]YB642 |
| Health Research Project of Guizhou Province |
No. gzwkj2024-324 |
| Health Research Project of Guizhou Province |
No. gzwkj2024-103 |
| WBE Liver Fibrosis Foundation |
No. CFHPC2025028 |
| Beijing Liver and Gallbladder Mutual Aid Public Welfare Foundation Artificial Liver Special Fund |
No. iGandanF-1082024-Rgg018 |
| Student Innovation and Entrepreneurship Training Program of Zunyi Medical University |
No. S2024106612360 |
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| Corresponding Author |
Yi-Huai He, MD, Department of Infectious Diseases, Affiliated Hospital of Zunyi Medical University, No. 149 Dalian Road, Huichuan District, Zunyi 563000, Guizhou Province, China. 993565989@qq.com |
| Key Words |
Cell-type-specific functions; Dual roles; Liver diseases; Mixed lineage kinase domain-like protein; Necroptosis |
| Core Tip |
Mixed lineage kinase domain-like protein (MLKL) functions to mediate necroptosis, inhibit autophagy, and regulate inflammatory responses. The MLKL exhibits different functions in various types of liver cells, leading to diverse manifestations of different liver diseases. This complexity not only brings challenges in understanding the roles of MLKL in liver diseases, but also presents an obstacle in developing therapeutic strategies for targeting MLKL. Here, we briefly review the functions of MLKL and analyze its specific roles in different types of liver cells, aiming to provide clear strategies for precisely targeting MLKL in the treatment of liver diseases. |
| Publish Date |
2025-04-11 02:19 |
| Citation |
Liang MX, Zhou Y, Li SQ, Xiang WS, Pan ZQ, Chen YH, He YH. Mixed lineage kinase domain-like protein in liver diseases: Cell-type-specific functions and dual roles. World J Gastroenterol 2025; 31(14): 104523 |
| URL |
https://www.wjgnet.com/1007-9327/full/v31/i14/104523.htm |
| DOI |
https://dx.doi.org/10.3748/wjg.v31.i14.104523 |
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