| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Letter to the Editor |
| Article Title |
Triglyceride-glucose index in predicting gastric cancer prognosis: A need for caution
|
| Manuscript Source |
Invited Manuscript |
| All Author List |
Yi-Fan Zhao, Jia-Hui Lv, De-Fang Chen, Zhi-Hui Wang, Yun Teng, Michael Ntim, Min Xia, Shao Li and Bin Wang |
| ORCID |
|
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| National Natural Sciences Foundation of China |
82301700 and 82471464 |
| Liaoning Province Natural Science Foundation Project |
2023-MS-266 and 2024-MS-157 |
| Youth Talent Cultivation Fund Key Project of Dalian Medical University |
|
| Scientific Research Projects from Wuhan Municipal Health Commission |
WX23Z26 |
| Research Project Plan of the Qingpu Branch of Zhongshan Hospital |
QYT2023-02 |
|
| Corresponding Author |
Bin Wang, Liaoning Provincial Key Laboratory of Cerebral Diseases, College of Basic Medical Sciences, National-Local Joint Engineering Research Center for Drug Research, Dalian Medical University, No. 9 West Section, Lvshun South Road, Dalian 116000, Liaoning Province, China. wb101900@126.com |
| Key Words |
Triglyceride-glucose index; Gastric cancer; Prognostic biomarker; Glycolipid metabolism; Overall survival; Progression-free survival |
| Core Tip |
The triglyceride-glucose index, a straightforward marker of insulin resistance, demonstrates potential as a prognostic tool for gastric cancer, correlating with diminished overall survival and progression-free survival. However, its limited cancer specificity, inconsistent cutoff values, and ambiguous mechanistic role in tumor progression necessitate cautious interpretation. Future research should aim to integrate the triglyceride-glucose index with other cancer-specific biomarkers to enhance prognosis prediction and tailor treatment strategies. Prospective, multicenter studies are crucial for validating its clinical utility. |
| Publish Date |
2025-05-13 08:31 |
| Citation |
Zhao YF, Lv JH, Chen DF, Wang ZH, Teng Y, Ntim M, Xia M, Li S, Wang B. Triglyceride-glucose index in predicting gastric cancer prognosis: A need for caution. World J Gastroenterol 2025; 31(18): 104525 |
| URL |
https://www.wjgnet.com/1007-9327/full/v31/i18/104525.htm |
| DOI |
https://dx.doi.org/10.3748/wjg.v31.i18.104525 |
